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2020

A Comprehensive Workflow for Applying Single-Cell Clustering and Pseudotime Analysis to Flow Cytometry Data

Melsen, J. E., van Ostaijen-Ten Dam, M. M., Lankester, A. C., Schilham, M. W. & van den Akker, E. B., 2020, In : Journal of immunology (Baltimore, Md. : 1950). 205, 3, p. 864-871 8 p.

Research output: Contribution to journalArticleScientificpeer-review

A data-driven methodology reveals novel myofiber clusters in older human muscles

Raz, Y., van den Akker, E. B., Roest, T., Riaz, M., van de Rest, O., Suchiman, H. E. D., Lakenberg, N., Stassen, S. A., Reinders, M. J. T. & More Authors, 2020, In : FASEB Journal. 34, 4, p. 5525-5537 13 p.

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Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance

Rutten, J. W., Hack, R. J., Duering, M., Gravesteijn, G., Dauwerse, J. G., Overzier, M., van den Akker, E. B., Slagboom, E., Holstege, H. & More Authors, 2020, In : Neurology. 95, 13, p. e1835-e1843

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Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing

Arindrarto, W., Borràs, D. M., de Groen, R. A. L., van den Berg, R. R., Locher, I. J., van Diessen, S. A. M. E., Valk, P. J. M., Janssen, B. & van den Akker, E. B., 2020, In : Leukemia. 15 p.

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4 Citations (Scopus)
22 Downloads (Pure)

Integrating metabolomics, genomics and disease pathways in age-related macular degeneration: The EYE-RISK Consortium

Acar, İ. E., Lores-Motta, L., Colijn, J. M., Meester-Smoor, M. A., Verzijden, T., Cougnard-Gregoire, A., Ajana, S., van den Akker, E., van Duijn, C. M. & More Authors, 14 Jun 2020, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticleScientificpeer-review

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Liu, J., Lahousse, L., Nivard, M. G., Bot, M., Chen, L., van Klinken, J. B., van den Akker, E. B., Vojinovic, D., Milaneschi, Y. & More Authors, 2020, In : Nature Medicine. 26, 1, p. 110-117 8 p.

Research output: Contribution to journalArticleScientificpeer-review

4 Citations (Scopus)

Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter

Beekman, M., Schutte, B. A. M., Akker, E. B. V. D., Noordam, R., Dibbets-Schneider, P., de Geus-Oei, L. F., Deelen, J., Rest, O. V. D., Heemst, D. V. & More Authors, 1 May 2020, In : Molecular Nutrition and Food Research. 64, 10, p. 1-8 8 p., 1900818.

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2019

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

van der Lee, S. J., Knol, M. J., Chauhan, G., Satizabal, C. L., Smith, A. V., Hofer, E., Bis, J. C., van den Akker, E. B., Niessen, W. J. & More Authors, 2019, In : Communications Biology. 2, 1, p. 1-9 9 p., 285.

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4 Citations (Scopus)
40 Downloads (Pure)

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

Deelen, J., Kettunen, J., Fischer, K., van der Spek, A., Trompet, S., Boyd, A., Zierer, J., van den Akker, E. B., Ala-Korpela, M. & More Authors, 2019, In : Nature Communications. 10, 1, p. 1-8 8 p., 3346.

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20 Citations (Scopus)
50 Downloads (Pure)

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

van der Lee, S., Conway, O. J., Hansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hulsman, M., Tesi, N., Reinders, M. J. T. & More Authors, 2019, In : Acta Neuropathologica. 138, 2, p. 237-250 14 p.

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19 Citations (Scopus)
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Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

BBMRI Metabolomics Consortium & More Authors, 1 Dec 2019, In : Nature Communications. 11, 1, 11 p., 39.

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2 Citations (Scopus)
11 Downloads (Pure)
2018

Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile

Vrieling, F., Ronacher, K., Kleynhans, L., van den Akker, E., Walzl, G., Ottenhoff, T. H. M. & Joosten, S. A., 2018, In : EBioMedicine. 32, p. 192-200 9 p.

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14 Citations (Scopus)
19 Downloads (Pure)
2016

Pan-cancer subtyping in a 2D-map shows substructures that are driven by specific combinations of molecular characteristics

Taskesen, E., Huisman, S., Mahfouz, A., Krijthe, J., de Ridder, J., van de Stolpe, A., van den Akker, E., Verhaegh, W. & Reinders, M., 25 Apr 2016, In : Scientific Reports. 6, 13 p., 24949.

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12 Citations (Scopus)
29 Downloads (Pure)
2015

IL7R gene expression network associates with human healthy ageing

Passtoors, WM., van den Akker, EB., Deelen, J., Maier, A. B., van der Breggen, R., Jansen, R., Trompet, S., van Heemst, D., Derhovanessian, E., Pawelec, G., van Ommen, GJB., Slagboom, PE. & Beekman, M., 2015, In : Immunity and Ageing. 12, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
16 Citations (Scopus)

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

Bomer, N., den Hollander, WT., Ramos, YFM., Bos, SD., van der Breggen, R., Lakenberg, N., Pepers, BA., van Eeden, AE., Darvishan, A., Tobi, EW., Duijnisveld, BJ., van den Akker, EB., Heijmans, BT., van Roon-Mom, WMC., Verbeek, FJ., Osch, GJVM., Nelissen, RGHH., Slagboom, PE. & Meulenbelt, I., 2015, In : Annals of the Rheumatic Diseases: an international peer-reviewed journal for health professionals and researchers in the rheumatic diseases. 74, 8, p. 1571-1579 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
46 Citations (Scopus)
2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J. & van den Akker, EB., 2014, In : Human Molecular Genetics. 23, 16, p. 4420-4432 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
136 Citations (Scopus)

Genome wide DNA methylation profiling of osteoarthritic articular cartilage

den Hollander, W., Ramos, YF., Bos, SD., Bomer, N., van der Breggen, R., Lakenberg, N., Sliecker, R., Luijk, R., Tobi, EW., Duijnisveld, BJ., van den Akker, EB., Heijmans, BT., Slagboom, PE., Nelissen, RG. & Meulenbelt, I., 2014, In : Osteoarthritis and Cartilage. 22(suppl.), p. 1-2 2 p.

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Open Access

Low mitochondrial DNA content associates with familial longevity: The Leiden longevity study

van Leeuwen, N., Beekman, M., Deelen, J., van den Akker, EB., de Craen, AJM. & Slagboom, PE., 2014, In : Age. 36, 3, p. 1463-1470 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
12 Citations (Scopus)

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

van den Akker, EB., Passtoors, WM., Jansen, R., van Zwet, EW., Goeman, JJ., Hulsman, M., Emilsson, V., Perola, M., Wilemsen, G., Penninx, BWJH., Heijmans, BT., Maier, A. B., Boomsma, DI., Kok, JN., Slagboom, PE., Reinders, MJT. & Beekman, M., 2014, In : Aging Cell. 13, 2, p. 216-225 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
35 Citations (Scopus)
2013

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

Ye, K., Beekman, M., Lameijer, EW., Zhang, Y., Moed, MH., van den Akker, EB., Deelen, J., Houwing-Duistermaat, JJ., Kremer, D., Yahya Anvar, S., Laros, JFJ., Jones, D., Raine, K., Blackburne, B., Potluri, S., Long, Q., Guryev, V., van der Breggen, R., Westendorp, RJG., 't Hoen, PAC. & 8 others, den Dunnen, J., van Ommen, GJB., Willemsen, G., Pitss, SJ., Cox, DR., Ning, Z., Boomsma, DI. & Slagboom, PE., 2013, In : Twin Research and Human Genetics. 16, 6, p. 1026-1032 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
24 Citations (Scopus)

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

Deelen, J., Uh, H-W., Monajemi, R., van Heemst, D., Thijssen, PE., Böhringer, S., van den Akker, EB., de Craen, AJM., Rivadeneira, F., Uitterlinden, AG., Westendorp, RGJ., Goeman, JJ., Slagboom, PE., Houwing-Duistermaat, JJ. & Beekman, M., 2013, In : Age. 35, 1, p. 235-249 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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62 Citations (Scopus)

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., de Craen, AJM., Kirkwood, TBL., Maeve Rea, I., Poulain, M., Robine, JM., Valensin, S., Stazi, MA., Passarino, G., Deiana, L., Gonos, ES., Paternoster, L., Sørensen, TIA. & 20 others, Tan, Q., Helmer, Q., van den Akker, EB., Deelen, J., Martella, F., Cordell, HJ., Ayers, KL., Vaupel, JW., Tornwall, O., Johnson, TE., Schreiber, S., Lathrop, M., Skytthe, A., Westendorp, RJG., Christensen, K., Gampe, J., Nebel, A., Houwing-Duistermaat, JJ., Slagboom, PE. & Franceschi, C., 2013, In : Aging Cell. 12, 2, p. 184-193 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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113 Citations (Scopus)

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

Slieker, RC., Bos, SD., Goeman, JJ., Bovee, JVMG., Talens, RP., van der Breggen, R., Suchiman, HED., Lameijer, EW., Putter, H., van den Akker, EB., Zhang, Y., Jukema, JW., Slagboom, PE., Meulenbelt, I. & Heijmans, BT., 2013, In : Epigenetics & Chromatin. 6, 26, p. 1-12 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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144 Citations (Scopus)
2012

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

Passtoors, WM., Boer, JM., Goeman, JG., van den Akker, EB., Deelen, J., Zwaan, BJ., Scarborough, A., van der Breggen, R., Vossen, RHAM., Houwing-Duistermaat, JJ., van Ommen, GJB., Westendorp, RGJ., van Heemst, D., de Craen, AJM., White, AJ., Gunn, DA., Beekman, M. & Slagboom, PE., 2012, In : PLoS ONE. 7, 1, p. 1-10 10 p.

Research output: Contribution to journalArticleScientificpeer-review

30 Citations (Scopus)
2011

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

Lourdes Sampietro, M., Trompet, S., Verschuren, JJW., Talens, RP., Deelen, J., Heijmans, BT., de Winter, RJ., Tio, R. A., Doevendans, PAFM., Ganesh, SK., Nabel, EG., Westra, HJ., Franke, L., van den Akker, EB., Westendorp, RGJ., Zwinderman, AH., Kastrati, A., Koch, W., Slagboom, PE., de Knijff, P. & 1 others, Jukema, W. J., 2011, In : Human Molecular Genetics. 22, 5, p. 1-10 10 p.

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

Deelen, J., Beekman, M., Uh, H-W., Helmer, Q., Kunigas, M., Christiansen, L., Kremer, D., van der Breggen, R., Suchiman, HED., Lakenberg, N., van den Akker, EB., Passtoors, WM., Tiemeier, H., van Heemst, D., de Craen, AJM., Rivadeneira, F., de Geus, EJ., Perola, M., van der Ouderaa, FJ., Gunn, DA. & 8 others, Boomsma, DI., Uitterlinden, AG., Christensen, K., van Duijn, CM., Heijmans, BT., Houwing-Duistermaat, JJ., Westendorp, RGJ. & Slagboom, PE., 2011, In : Aging Cell. 10, 4, p. 656-698 43 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
187 Citations (Scopus)

Integrating protein family sequence similarities with gene expression to find signature gene networks in breast cancer metastasis

Babaei, S., van den Akker, EB., de Ridder, J. & Reinders, MJT., 2011, In : Lecture Notes in Computer Science. 7036, p. 247-259 13 p.

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures forclassifying breast cancer metastasis

van den Akker, EB., Verbruggen, B., Heijmans, B., Beekman, M., Kok, J. & Slagboom, E., 2011, In : Journal of Integrative Bioinformatics. 16, 8, p. 1-17 17 p.

Research output: Contribution to journalArticleScientificpeer-review