J.J. Heijnen

Search results

• 2010

  Time-scale based metabolic network reduction for 13C flux analysis

  Zhao, Z., Wahl, SA., Verheijen, PJT., Heijnen, JJ. & van Gulik, WM., 2010.

  Research output: Contribution to conference › Poster › Professional

• Towards the kinetic effect of ethanol in Saccharomyces cerevisiae

  Bekers, KM., van Gulik, WM. & Heijnen, JJ., 2010.

  Research output: Contribution to conference › Poster › Professional

• Towards the kinetic effect of ethanol in Saccharomyces cerevisiae

  Bekers, KM., van Gulik, WM. & Heijnen, JJ., 2010.

  Research output: Contribution to conference › Poster › Professional
• 2009

  A comprehensive method for the quantifaction of the non-oxidative pentose phosphate pathway inter-mediates in Saccaromyces cerevisiae by GC-IDMS

  van Dam, JC., Cipollina, C., ten Pierick, A. & Heijnen, JJ., 2009.

  Research output: Contribution to conference › Poster › Professional

• Dynamic in vivo response of aerobic chemostat cultivated E. coli to a substrate pulse

  Taymaz, H., Maleki Seifar, R., Ras, C., ten Pierick, A., van Gulik, WM. & Heijnen, JJ., 2009.

  Research output: Contribution to conference › Poster › Professional

• Dynamic response of fermentative metabolism of Escherichia coli to aerobic and anaerobic glucose pulses

  Lara, A. R., Taymaz, H., Mashego, MR., van Gulik, WM., Heijnen, JJ., Ramirez, OT. & van Winden, W., 2009.

  Research output: Contribution to conference › Poster › Professional

• Identification of lin-log kinetics for the central metabolism of E. coli

  Bernaerts, K., Taymaz, H., Heijnen, JJ., van Gulik, WM. & Verheijen, PJT., 2009.

  Research output: Contribution to conference › Poster › Professional

• Quantitative analysis of free intracellular nucleotides using ion pair liquid chromatography isotope dilution tandem mass spectrometry

  Maleki Seifar, R., Ras, C., van Dam, JC., van Gulik, WM., Heijnen, JJ. & van Winden, WA., 2009.

  Research output: Contribution to conference › Poster › Professional
• 2008

  Development of an accurate method for intracellular metabolome analysis in E. coli for in vivo kinetic analysis

  Taymaz, H., de Mey, M., Ras, C., ten Pierick, A., Maleki Seifar, R., van Dam, JC., Heijnen, JJ. & van Gulik, WM., 2008.

  Research output: Contribution to conference › Poster › Professional

• Development of an accurate method for intracellular metabolome analysis in E. coli for in vivo kinetic analysis

  Taymaz, H., de Mey, M., Ras, C., ten Pierick, A., Maleki Seifar, R., van Dam, JC., Heijnen, JJ. & van Gulik, WM., 2008.

  Research output: Contribution to conference › Poster › Professional

• Quantitative analysis of metabolites in complex biological samples using ion pair reversed phase liquid chromatography isotope dilution mass spectrometry

  Maleki Seifar, R., Zhao, Z., van Dam, JC., van Winden, WA., van Gulik, WM. & Heijnen, JJ., 2008.

  Research output: Contribution to conference › Poster › Professional

• Reliable quantification of intracellular metabolites in Escherichia Coli

  Taymaz, H., de Mey, M., Ras, C., ten Pierick, A., Maleki Seifar, R., van Dam, JC., van Gulik, WM. & Heijnen, JJ., 2008.

  Research output: Contribution to conference › Poster › Professional

• Simple non-stationary 13C local flux quantification

  Zhao, Z., Heijnen, JJ., van Gulik, WM. & Verheijen, PJT., 2008.

  Research output: Contribution to conference › Poster › Professional

• Wash-in of U-13C glucose into E.coli cells cultivated in a carbon limited chemostat

  de Mey, M., Taymaz, H., Lequeux, G., Ras, C., van Dam, JC., van Winden, WA., Verheijen, PJT., van Gulik, WM. & Heijnen, JJ., 2008.

  Research output: Contribution to conference › Poster › Professional
• 2007

  Development of large scale dynamic metabolic model of penicillium chrysogenum using linlog kinetics

  Nikerel, IE., Blankestijn, RMP., van Gulik, WM., van Winden, WA., Verheijen, PJT. & Heijnen, JJ., 2007.

  Research output: Contribution to conference › Poster › Scientific

• Identification of metabolic network structure based on stimulus-response experiments

  Bellomo, D., de Ridder, D., Heijnen, JJ., Reinders, MJT., van Winden, WA. & Verheijen, PJT., 2007.

  Research output: Contribution to conference › Poster › Professional

• Identification of metabolic network structure based on stimulus-response experiments

  Bellomo, D., de Ridder, D., Heijnen, JJ., Reinders, MJT., van Winden, WA. & Verheijen, PJT., 2007.

  Research output: Contribution to conference › Poster › Professional

• Metabolic network reconstruction: the intersection of data-driven and knowledge-based approaches

  de Groot, MJL., Bellomo, D., van Winden, WA., de Ridder, D., Heijnen, JJ., Reinders, MJT. & Verheijen, PJT., 2007.

  Research output: Contribution to conference › Poster › Professional

• Quantitative analysis of intermediates and by-products of the penicillium chrysogenum biosynthesis pathway using LC-ESI-MS/MS

  Maleki Seifar, R., van Dam, JC. & Heijnen, JJ., 2007.

  Research output: Contribution to conference › Poster › Professional

• Reconstructing metabolic networks from perturbation experiments

  Bellomo, D., Rossell Aragort, SL., de Ridder, D., Heijnen, JJ., Reinders, MJT., van Winden, WA. & Verheijen, PJT., 2007.

  Research output: Contribution to conference › Poster › Professional

• Reconstructing metabolic networks from perturbation experiments

  Bellomo, D., de Ridder, D., Heijnen, S., Reinders, MJT., van Winden, W. & Verheijen, PJT., 2007.

  Research output: Contribution to conference › Poster › Professional

• The metabolic response of P. chrysogenum to substrate concentration gradients

  de Jonge, LP., Knoll, J., Ras, C., ten Pierick, A., van Gulik, WM. & Heijnen, JJ., 2007.

  Research output: Contribution to conference › Poster › Professional
• 2006

  LC-ESI-MS/MS Analysis of intracellular PenG, intermediates and byproducts in cultivated Penicillium Chrysogenum cells

  Maleki Seifar, R., van Dam, JC. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional

• Mixed substrate metabolism of Penicillium chrysogenum

  Zhao, Z., van Gulik, WM. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional

• Quantitative analysis of metabolites from Penicillium chrysogenum using LC-MS/MS

  Maleki Seifar, R., Nasution, U., van Dam, JC. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional

• Removal of product crystals during fermentation

  Cuellar, MC., Straathof, AJJ., Heijnen, JJ. & van der Wielen, LAM., 2006.

  Research output: Contribution to conference › Poster › Scientific

• Validation of a mini bioreactor for step wise perturbation experiments

  Aboka, FO., van Winden, WA. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional

• Validation of a mini bioreactor for step wise perturbation experiments

  Aboka, FO., van Winden, WA. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional

• Vertical genomics: short-term dynamics of central metabolism and glycolytic genes in S. cerevisiae

  Canelas, A., Bouwman, J., Bakker, BM., van Gulik, WM. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional

• Vertical genomics: short-term dynamics of central metabolism and glycolytic genes in S. cerevisiae

  Canelas, A., Bouwman, J., Bakker, BM., van Gulik, WM. & Heijnen, JJ., 2006.

  Research output: Contribution to conference › Poster › Professional
• 2005

  LC-MS-based analysis of 13C-labeled intracellular metabolites for fluxome profiling of a synchronised S. cerevisiae culture

  Costenoble, RS., Muller, D., Bart, T., Reuss, M., van Winden, WA. & Heijnen, JJ., 2005.

  Research output: Contribution to conference › Poster › Professional

• LC-MS based analysis of 13C-labeled intracellular metabolites for fluxome profiling of S. cerevisiae

  Costenoble, RS., van Winden, WA. & Heijnen, JJ., 2005.

  Research output: Contribution to conference › Poster › Professional

• Optimizing mixing in micro-bioreactors used for high throughput screening of suitable biocatalysts in industrial fermentation (niet eerder opgenomen)

  Li, X., Ottens, M., van Dedem, GWK., van der Wielen, LAM., van Leeuwen, M., van Gulik, WM., Heijnen, JJ., Krommenhoek, EE., Gardeniers, JGE. & van den Berg, A., 2005.

  Research output: Contribution to conference › Poster › Scientific
• 2004

  13C-labeling based metabolic flux analysis of Penicillium chrysogenum under producing and non-producing conditions

  Kleijn, RJ., van Winden, WA., Ras, C., van Dam, JC., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• An improved bioscope design: a system for continuous pulse experiments

  Mashego, MR., Corcoi, JR., Vinke, JL., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• An improved Bioscope design: a system for continuous pulse experiments

  Mashego, MR., Vinke, JL., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• Application of metabolome data in functional genomics: an integrative strategy

  Wu, L., van Gulik, WM., van Winden, WA. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• Combining microbial growth, bio-reduction and in-situ product crystallization during levodione crystals production

  Buque, EM., Straathof, AJJ., Heijnen, JJ. & van der Wielen, LAM., 2004.

  Research output: Contribution to conference › Poster › Professional

• Dynamic simulation of the glycolysis in Saccharomyces cerevisiae using linlog kinetics

  Nikerel, IE., van Winden, WA., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• Impact of experimental accuracy on metabolic redesign

  Schmid, JW., Mauch, K., Heijnen, JJ. & Reuss, M., 2004.

  Research output: Contribution to conference › Poster › Professional

• Metabolome analysis by isotope dilution mass spectrometry using fully-labeled cell extracts as internal standards

  Wu, L., Mashego, MR., van Dam, JC., ten Pierick, A., Vinke, JL., Ras, C., van Winden, WA., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• Microbial growth and bio-reduction concomitant with in-situ product crystallization during levodione crystals production

  Buque, EM., Straathof, AJJ., Heijnen, JJ. & van der Wielen, LAM., 2004.

  Research output: Contribution to conference › Poster › Professional

• Removal of product crystals during fermentation

  Cuellar, MC., Straathof, AJJ., Heijnen, JJ. & van der Wielen, LAM., 2004.

  Research output: Contribution to conference › Poster › Professional

• Removal of product crystals during fermentation

  Cuellar, MC., Straathof, AJJ., Heijnen, JJ. & van der Wielen, LAM., 2004.

  Research output: Contribution to conference › Poster › Professional

• Stimulus response techniques for in vivo kinetics of Saccharomyces cerevisiae: Intracellular pH measurement

  Kresnowati, MTAP., Groothuizen, MK., van Winden, WA., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• The biocurve: a mini bioreactor for stepwise uptake rate variation experiments

  Aboka, FO., van Winden, WA., van Gulik, WM. & Heijnen, JJ., 2004.

  Research output: Contribution to conference › Poster › Professional

• The monolith reactor - a novel reactor concept for biological gas purification

  Ebrahimi, S., Kleerebezem, R., Heijnen, JJ., van Loosdrecht, MCM. & Kreutzer, MT., 2004.

  Research output: Contribution to conference › Poster › Professional
• 2003

  Quantification of cell metabolites with isotope silution mass spectrometry applying uniformly 13C labeled cell extracts

  van Dam, JC., Wu, L., ten Pierick, A., van Winden, WA., van Gulik, WM. & Heijnen, JJ., 2003.

  Research output: Contribution to conference › Poster › Professional