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Research Output

2020

Contribution of Complex I NADH Dehydrogenase to Respiratory Energy Coupling in Glucose-Grown Cultures of Ogataea parapolymorpha

Juergens, H., Hakkaart, X. D. V., Bras, J. E., Vente, A., Wu, L., Benjamin, K. R., Pronk, J. T., Daran-Lapujade, P. & Mans, R., 2020, In : Applied and Environmental Microbiology. 86, 15, 18 p., e00678.

Research output: Contribution to journalArticleScientificpeer-review

Engineering Saccharomyces cerevisiae for Succinic Acid Production From Glycerol and Carbon Dioxide

Xiberras, J., Klein, M., de Hulster, E., Mans, R. & Nevoigt, E., 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 13 p., 566.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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1 Downloads (Pure)

Regulatory control circuits for stabilizing long-term anabolic product formation in yeast

D'Ambrosio, V., Dore, E., Di Blasi, R., van den Broek, M., Sudarsan, S., Horst, J. T., Ambri, F., Keasling, J. D., Mans, R. & More Authors, 2020, In : Metabolic Engineering. 61, p. 369-380

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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4 Downloads (Pure)

Weak Acid Permeation in Synthetic Lipid Vesicles and Across the Yeast Plasma Membrane

Gabba, M., Frallicciardi, J., van ’t Klooster, J., Henderson, R., Syga, Ł., Mans, R., van Maris, A. J. A. & Poolman, B., 2020, In : Biophysical Journal. 118, 2, p. 422-434 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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6 Citations (Scopus)
45 Downloads (Pure)
2019

Functional expression of a bacterial α-ketoglutarate dehydrogenase in the cytosol of Saccharomyces cerevisiae

Baldi, N., Dykstra, J. C., Luttik, M. A. H., Pabst, M., Wu, L., Benjamin, K. R., Vente, A., Pronk, J. T. & Mans, R., 2019, In : Metabolic Engineering. 56, p. 190-197

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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1 Citation (Scopus)
41 Downloads (Pure)
2018

A protocol for introduction of multiple genetic modifications in Saccharomyces cerevisiae using CRISPR/Cas9

Mans, R., Wijsman, M., Daran-Lapujade, P. & Daran, J. M., 2018, In : FEMS Yeast Research. 18, 7, 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
11 Citations (Scopus)
33 Downloads (Pure)

A toolkit for rapid CRISPR-SpCas9 assisted construction of hexose-transport-deficient Saccharomyces cerevisiae strains

Wijsman, M., Swiat, M. A., Marques, W. L., Hettinga, J. K., van den Broek, M., Torre Cortés, P. D. L., Mans, R., Pronk, J. T., Daran, J. M. & Daran-Lapujade, P., 2018, In : FEMS Yeast Research. 19, 1, 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
5 Citations (Scopus)
121 Downloads (Pure)

Combined engineering of disaccharide transport and phosphorolysis for enhanced ATP yield from sucrose fermentation in Saccharomyces cerevisiae

Marques, W. L., Mans, R., Henderson, R. K., Marella, E. R., Horst, J. T., Hulster, E. D., Poolman, B., Daran, J. M., Pronk, J. T., Gombert, A. K. & van Maris, A. J. A., 2018, In : Metabolic Engineering. 45, p. 121-133 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
11 Citations (Scopus)
58 Downloads (Pure)

Evaluation of a novel cloud-based software platform for structured experiment design and linked data analytics

Juergens, H., Niemeijer, M., Jennings-Antipov, L. D., Mans, R., Morel, J., van Maris, A. J. A., Pronk, J. T. & Gardner, T. S., 2018, In : Scientific Data. 5, 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2 Citations (Scopus)
20 Downloads (Pure)

Genome editing in Kluyveromyces and Ogataea yeasts using a broad-host-range Cas9/gRNA co-expression plasmid

Juergens, H., Varela, J. A., de Vries, A. R. G., Perli, T., Gast, V. J. M., Gyurchev, N. Y., Rajkumar, A. S., Mans, R., Pronk, J. T., Morrissey, J. P. & Daran, J. M. G., 2018, In : FEMS Yeast Research. 18, 3, 16 p., foy012.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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19 Citations (Scopus)
59 Downloads (Pure)

Genome Editing in Kluyveromyces and Ogataea Yeasts Using a Broad-Host-Range Cas9/gRNA Co-Expression Plasmid

Jürgens, H., Varela, J. A., Gorter de Vries, A., Perli, T., Gast, V., Gyurchev, N., Rajkumar, A. S., Mans, R., Pronk, J., Morrissey, J. P. & Daran, J. M., 2018.

Research output: Contribution to conferencePosterScientific

Genome Editing in Kluyveromyces and Ogataea Yeasts Using a Broad-Host-Range Cas9/gRNA Co-Expression Plasmid

Jürgens, H., Varela, J. A., Gorter de Vries, A., Perli, T., Gast, V., Gyurchev, N., Rajkumar, A. S., Mans, R., Pronk, J., Morrissey, J. P. & Daran, J. M., 2018.

Research output: Contribution to conferencePosterScientific

Laboratory evolution and physiological analysis of Saccharomyces cerevisiae strains dependent on sucrose uptake via the Phaseolus vulgaris Suf1 transporter

Marques, W. L., van der Woude, L. N., Luttik, M. A. H., van den Broek, M., Nijenhuis, J. M., Pronk, J. T., van Maris, A. J. A., Mans, R. & Gombert, A. K., 2018, In : Yeast. 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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19 Downloads (Pure)

Under pressure: evolutionary engineering of yeast strains for improved performance in fuels and chemicals production

Mans, R., Daran, J. M. G. & Pronk, J. T., 2018, In : Current Opinion in Biotechnology. 50, p. 47-56 10 p.

Research output: Contribution to journalReview articleScientificpeer-review

Open Access
File
49 Citations (Scopus)
200 Downloads (Pure)
2017

A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae

Mans, R., Hassing, E., Wijsman, M., Giezekamp, A., Pronk, J. T., Daran, J. M. & van Maris, A. J. A., 1 Dec 2017, In : FEMS Yeast Research. 17, 8, fox085.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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6 Citations (Scopus)
28 Downloads (Pure)

Elimination of sucrose transport and hydrolysis in Saccharomyces cerevisiae: a platform strain for engineering sucrose metabolism

Marques, W. L., Mans, R., Marella, E. R., Cordeiro, R. L., van den Broek, M., Daran, J. M. G., Pronk, J. T., Gombert, A. K. & van Maris, A. J. A., 2017, In : FEMS Yeast Research. 17, 1, 11 p., fox006.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
14 Citations (Scopus)
35 Downloads (Pure)

Specific Arabidopsis thaliana malic enzyme isoforms can provide anaplerotic pyruvate carboxylation function in Saccharomyces cerevisiae

Badia, M. B., Mans, R., Lis, A. V., Tronconi, M. A., Arias, C. L., Maurino, V. G., Andreo, C. S., Drincovich, M. F., van Maris, A. J. A. & Gerrard Wheeler, M. C., 2017, In : The FEBS Journal. 284, 4, p. 654-665

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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5 Citations (Scopus)
20 Downloads (Pure)

Strategies and genetic tools for engineering free-energy conservation in yeast

Mans, R., 2017, 183 p.

Research output: ThesisDissertation (TU Delft)

Open Access
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10 Downloads (Pure)
2016

Sucrose hydrolysis in Saccharomyces cerevisiae: Who are the players?

Marques, W., Mans, R., Cordeiro, R. L., Marella, E. R., van den Broek, M., Daran, J. M., Pronk, J., Gombert, A. K. & van Maris, T., 2016.

Research output: Contribution to conferencePosterProfessional

2015

CRISPR/Cas9: a molecular swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae

Mans, R., van Rossum, HM., Wijsman, M., Backx, A., Kuijpers, NGA., van den Broek, MA., Daran-Lapujade, PAS., Pronk, JT., van Maris, AJA. & Daran, JM., 2015.

Research output: Contribution to conferencePosterProfessional

185 Citations (Scopus)

CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae

Mans, R., van Rossum, HM., Wijsman, M., Backx, A., Kuijpers, NGA., van den Broek, MA., Daran-Lapujade, PAS., Pronk, JT., van Maris, AJA. & Daran, JM., 2015, In : FEMS Yeast Research. 15, 2, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
185 Citations (Scopus)

GDP – Yeast strains with improved osmotolerance

Pronk, JT., Guadalupe Medina, VG., van Maris, AJA., Oud, BLP., Metz, B. & Mans, R., 2015, IPC No. Applicant: DSM IP ASSETS B.V, Patent No. WO 2014180820 A2, Priority date 8 Jan 2015

Research output: Patent

2014

An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme

Romagnoli, G., Verhoeven, M., Mans, R., Fleury Rey, Y., Bel-Rhlid, R., van den Broek, MA., Maleki Seifar, R., ten Pierick, A., Thompson, M., Muller, V., Wahl, SA., Pronk, J. T. & Daran, JM., 2014, In : Molecular Microbiology. 93, p. 369-389 21 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
10 Citations (Scopus)

Evolutionary engineering of a glycerol-3-phosphate dehydrogenase-negative, acetate-reducing Saccharomyces cerevisiae strain enables anaerobic growth at high glucose concentrations

Guadalupe Medina, VG., Metz, B., Oud, B., Der Graaf, CM., Mans, R., Pronk, JT. & van Maris, AJA., 2014, In : Microbial Biotechnology. 7, 1, p. 44-53 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
22 Citations (Scopus)

GDP: Yeast strains with improved osmotolerance

Pronk, JT., Guadalupe Medina, VG., van Maris, AJA., Oud, BLP., Metz, B. & Mans, R., 2014, IPC No. Applicant: DSM IP Assets BV, Patent No. WO 2014180820 A2, Priority date 13 Nov 2014

Research output: Patent

2013

Increasing free-energy (ATP) conservation in maltose-grown Saccharomyces cerevisiae by expression of a heterologous maltose phosphorylase

Mans, R., Marques, WL., de Kok, S., Yilmaz, D., Suir, E., Pronk, JT., Daran, JM. & van Maris, AJA., 2013.

Research output: Contribution to conferenceAbstractScientific