Dual-function MR-guided hyperthermia: An innovative integrated approach and experimental demonstration of proof of principle

Kemal Sumser*, Gennaro G. Bellizzi, Ria Forner, Tomas Drizdal, Juan A. Hernandez Tamames, Gerard C. van Rhoon, Margarethus M. Paulides

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.

Original languageEnglish
Article number9152076
Pages (from-to)712-717
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Volume68
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Hyperthermia
  • MR thermometry
  • MR-guided treatment
  • Phased array integration
  • Radiofrequency

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