TY - JOUR
T1 - Dual-function MR-guided hyperthermia
T2 - An innovative integrated approach and experimental demonstration of proof of principle
AU - Sumser, Kemal
AU - Bellizzi, Gennaro G.
AU - Forner, Ria
AU - Drizdal, Tomas
AU - Hernandez Tamames, Juan A.
AU - van Rhoon, Gerard C.
AU - Paulides, Margarethus M.
PY - 2021/2
Y1 - 2021/2
N2 - Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.
AB - Temperature monitoring plays a central role in improving clinical effectiveness of adjuvant hyperthermia. The potential of magnetic resonance thermometry for treatment monitoring purposes led to several MR-guided hyperthermia approaches. However, the proposed solutions were sub-optimal due to technological and intrinsic limitations. These hamper achieving target conformal heating possibilities (applicator limitations) and accurate thermometry (inadequate signal-to-noise-ratio (SNR)). In this work, we studied proof of principle of a dual-function hyperthermia approach based on a coil array (64 MHz, 1.5 T) that is integrated in-between a phased array for heating (434 MHz) for maximum signal receive in order to improve thermometry accuracy. Hereto, we designed and fabricated a superficial hyperthermia mimicking planar array setup to study the most challenging interactions of generic phased-array setups in order to validate the integrated approach. Experiments demonstrated that the setup complies with the superficial hyperthermia guidelines for heating and is able to improve SNR at 2-4 cm depth by 17%, as compared to imaging using the body coil. Hence, the results showed the feasibility of our dual-function MR-guided hyperthermia approach as basis for the development of application specific setups.
KW - Hyperthermia
KW - MR thermometry
KW - MR-guided treatment
KW - Phased array integration
KW - Radiofrequency
UR - http://www.scopus.com/inward/record.url?scp=85096797363&partnerID=8YFLogxK
U2 - 10.1109/tbme.2020.3012734
DO - 10.1109/tbme.2020.3012734
M3 - Article
C2 - 32746075
AN - SCOPUS:85096797363
SN - 0018-9294
VL - 68
SP - 712
EP - 717
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 2
M1 - 9152076
ER -