A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS

Drew A. Hall; Richard S. Gaster; Kofi A.A. Makinwa; Shan X. Wang; Boris Murmann

doi:10.1109/JSSC.2013.2245058

A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS

Drew A. Hall, Richard S. Gaster, Kofi A.A. Makinwa, Shan X. Wang, Boris Murmann

Electronic Instrumentation

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Abstract

Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog frontend and a compact ΣΔ modulator (0.054 mm2) with 84 dB of dynamic range and an input referred noise of 49
nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacement
for optical protein microarrays while also providing real-time kinetics monitoring.

Original language	English
Pages (from-to)	1290-1301
Number of pages	12
Journal	IEEE Journal of Solid State Circuits
Volume	48
Issue number	5
DOIs	https://doi.org/10.1109/JSSC.2013.2245058
Publication status	Published - 2013

Bibliographical note

Accepted author version

Keywords

Biochip
biosensor
GMR spin-valve
magnetic biosensor
proteomics
sigma delta modulator

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/JSSC.2013.2245058

2049639 - JSSC2245058Accepted author manuscript, 1.9 MB

Cite this

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title = "A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS",

abstract = "Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog frontend and a compact ΣΔ modulator (0.054 mm2) with 84 dB of dynamic range and an input referred noise of 49nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacementfor optical protein microarrays while also providing real-time kinetics monitoring.",

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AU - Hall, Drew A.

AU - Gaster, Richard S.

AU - Makinwa, Kofi A.A.

AU - Wang, Shan X.

AU - Murmann, Boris

N1 - Accepted author version

PY - 2013

Y1 - 2013

N2 - Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog frontend and a compact ΣΔ modulator (0.054 mm2) with 84 dB of dynamic range and an input referred noise of 49nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacementfor optical protein microarrays while also providing real-time kinetics monitoring.

AB - Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog frontend and a compact ΣΔ modulator (0.054 mm2) with 84 dB of dynamic range and an input referred noise of 49nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacementfor optical protein microarrays while also providing real-time kinetics monitoring.

KW - Biochip

KW - biosensor

KW - GMR spin-valve

KW - magnetic biosensor

KW - proteomics

KW - sigma delta modulator

U2 - 10.1109/JSSC.2013.2245058

DO - 10.1109/JSSC.2013.2245058

M3 - Article

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SP - 1290

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JO - IEEE Journal of Solid State Circuits

JF - IEEE Journal of Solid State Circuits

IS - 5

ER -

A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS

Abstract

Bibliographical note

Keywords

UN SDGs

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