A 3D microelectrode array to record neural activity at different tissue depths

T.M. de Rijk, Michel Hu, Jean-Philippe Frimat, Arn M.J.M. van den Maagdenberg, P.M. Sarro, M. Mastrangeli

Research output: Contribution to conferencePosterScientific

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Abstract

In vitro study of high-level neurobiological systems requires three-dimensional (3D) neuronal cultures [1]. Meas-uring responses along all three spatial dimensions is critical to record electric activity inside 3D neuronal models, such as organoids and other 3D brain tissue constructs. However, this lies beyond the capacity of 2D microelec-trode arrays (MEAs) [2]. We present planar arrays of 3D micro-pyramids, whereby each micro-pyramid supports multiple, electrically distinct and vertically stacked microelectrodes. The 3D microarrays were produced by wafer-scale micromachining and assembled onto printed circuit boards (PCBs) conforming to MEA readout standards.
Original languageEnglish
Number of pages1
Publication statusPublished - Jul 2020
EventEuropean Organ-on-Chip Society Conference (EUROoCS Conference 2020) - Online
Duration: 8 Jul 20209 Jul 2020
https://euroocs.eu/annual-euroocs-conference-2020/

Conference

ConferenceEuropean Organ-on-Chip Society Conference (EUROoCS Conference 2020)
Period8/07/209/07/20
OtherVirtual/online event due to COVID-19
Internet address

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    de Rijk, T. M., Hu, M., Frimat, J-P., van den Maagdenberg, A. M. J. M., Sarro, P. M., & Mastrangeli, M. (2020). A 3D microelectrode array to record neural activity at different tissue depths. Poster session presented at European Organ-on-Chip Society Conference (EUROoCS Conference 2020), .