A cerium-based metal-organic framework as adsorbent for the 99Mo/99mTc generator

Chao Ma, Hubert T. Wolterbeek, Antonia G. Denkova*, Pablo Serra Crespo

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of 99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for 99Mo/99mTc generators.

Original languageEnglish
Article number121218
Number of pages7
JournalSeparation and Purification Technology
Publication statusPublished - 2022


  • Mo/Tc generator
  • Adsorption mechanism
  • Molybdenum
  • UiO-66 (Ce)

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