A cerium-based metal-organic framework as adsorbent for the 99Mo/99mTc generator

Chao Ma; Hubert T. Wolterbeek; Antonia G. Denkova; Pablo Serra Crespo

doi:10.1016/j.seppur.2022.121218

A cerium-based metal-organic framework as adsorbent for the ⁹⁹Mo/^99mTc generator

Chao Ma, Hubert T. Wolterbeek, Antonia G. Denkova^*, Pablo Serra Crespo

^*Corresponding author for this work

RST/Applied Radiation & Isotopes

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the ⁹⁹Mo/^99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive ⁹⁹Mo was applied. A ⁹⁹Mo/^99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of ^99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for ⁹⁹Mo/^99mTc generators.

Original language	English
Article number	121218
Number of pages	7
Journal	Separation and Purification Technology
Volume	295
DOIs	https://doi.org/10.1016/j.seppur.2022.121218
Publication status	Published - 2022

Keywords

Mo/Tc generator
Adsorption mechanism
Molybdenum
UiO-66 (Ce)

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10.1016/j.seppur.2022.121218

1-s2.0-S1383586622007754-mainFinal published version, 4.3 MBLicence: CC BY

Cite this

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title = "A cerium-based metal-organic framework as adsorbent for the 99Mo/99mTc generator",

abstract = "The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of 99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for 99Mo/99mTc generators.",

keywords = "Mo/Tc generator, Adsorption mechanism, Molybdenum, UiO-66 (Ce)",

author = "Chao Ma and Wolterbeek, {Hubert T.} and Denkova, {Antonia G.} and {Serra Crespo}, Pablo",

year = "2022",

doi = "10.1016/j.seppur.2022.121218",

language = "English",

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journal = "Separation and Purification Technology",

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T1 - A cerium-based metal-organic framework as adsorbent for the 99Mo/99mTc generator

AU - Ma, Chao

AU - Wolterbeek, Hubert T.

AU - Denkova, Antonia G.

AU - Serra Crespo, Pablo

PY - 2022

Y1 - 2022

N2 - The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of 99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for 99Mo/99mTc generators.

AB - The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the 99Mo/99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was governed by hydrogen bonds, Ce-O-Mo coordination, π-anions and electrostatic interaction. Additionally, the adsorbent exhibited excellent radiation stability and good adsorption performance when radioactive 99Mo was applied. A 99Mo/99mTc generator was fabricated with UiO-66 (Ce) as adsorbent and its performance was evaluated over two weeks. The elution results showed that 92 ± 3% of 99mTc elution efficiency could be obtained with negligible cerium breakthrough, showing the great potential of UiO-66 (Ce) as adsorbent for 99Mo/99mTc generators.

KW - Mo/Tc generator

KW - Adsorption mechanism

KW - Molybdenum

KW - UiO-66 (Ce)

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DO - 10.1016/j.seppur.2022.121218

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SN - 1383-5866

VL - 295

JO - Separation and Purification Technology

JF - Separation and Purification Technology

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ER -

A cerium-based metal-organic framework as adsorbent for the ⁹⁹Mo/^99mTc generator

Abstract

Keywords

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