A compact microscope for voltage imaging

Xin Meng, Lex Huismans, Teun Huijben, Greta Szabo, Ruud Van Tol, Izak De Heer, Srividya Ganapathy, Daan Brinks*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Voltage imaging and optogenetics offer new routes to optically detect and influence neural dynamics. Optimized hardware is necessary to make the most of these new techniques. Here we present the Octoscope, a versatile, multimodal device for all-optical electrophysiology. We illustrate its concept and design and demonstrate its capability to perform both 1-photon and 2-photon voltage imaging with spatial and temporal light patterning, in both inverted and upright configurations, in vitro and in vivo.

Original languageEnglish
Article number054004
JournalJournal of Optics (United Kingdom)
Volume24
Issue number5
DOIs
Publication statusPublished - 2022

Keywords

  • electrophysiology
  • microscopy
  • neuroscience

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