A deeper shade of green: Inspiring sustainable drug manufacturing

Frank Roschangar; Juan Colberg; Peter J. Dunn; Fabrice Gallou; John D. Hayler; Stefan G. Koenig; Michael E. Kopach; David K. Leahy; Ingrid Mergelsberg; John L. Tucker; Roger A. Sheldon; Chris H. Senanayake

doi:10.1039/c6gc02901a

A deeper shade of green: Inspiring sustainable drug manufacturing

Frank Roschangar^*, Juan Colberg, Peter J. Dunn, Fabrice Gallou, John D. Hayler, Stefan G. Koenig, Michael E. Kopach, David K. Leahy, Ingrid Mergelsberg, John L. Tucker, Roger A. Sheldon, Chris H. Senanayake

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

90 Citations (Scopus)

Abstract

Green and sustainable drug manufacturing go hand in hand with forward-looking visions seeking to balance the long-term sustainability of business, society, and the environment. However, a lack of harmonization among available metrics has inhibited opportunities for green chemistry in industry. Moreover, inconsistent starting points for analysis and neglected complexities for diverse manufacturing processes have made developing objective goals a challenge. Herein we put forward a practical strategy to overcome these barriers using data from in-depth analysis of 46 drug manufacturing processes from nine large pharmaceutical firms, and propose the Green Aspiration Level as metric of choice to enable the critically needed consistency in smart green manufacturing goals. In addition, we quantify the importance of green chemistry in the often overlooked, yet enormously impactful, outsourced portion of the supply chain, and introduce the Green Scorecard as a value added sustainability communication tool.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Green Chemistry
Volume	19
Issue number	1
DOIs	https://doi.org/10.1039/c6gc02901a
Publication status	Published - 2017

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AU - Koenig, Stefan G.

AU - Kopach, Michael E.

AU - Leahy, David K.

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AU - Tucker, John L.

AU - Sheldon, Roger A.

AU - Senanayake, Chris H.

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A deeper shade of green: Inspiring sustainable drug manufacturing

Abstract

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