A highly sensitive capacitive displacement sensor for force measurement integrated in an engineered heart tissue platform

M. Dostanic, F. Pfaiffer, Mahdieh Shojaei Baghini, Laura Windt, Maury Wiendels, Berend van Meer, C. L. Mummery, Pasqualina M Sarro, Massimo Mastrangeli

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

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Abstract

We present a novel capacitive displacement sensor integrated in an engineered heart tissue (EHT) platform to measure tissue contractile properties in-situ. Co-planar spiral capacitors were integrated into the elastomeric substrate underneath the two micropillars of a previously developed EHT platform. The capacitor plates are displaced by the tension and compression that occurs in the substrate when the micropillars bend under contractile tissue force. For a contraction force of ~200 µN, applied in the middle of pillar length, the expected change in base capacitance is in the aF range. Readout of such low capacitance changes was achieved using a commercial low-noise high-sensitivity device. Characterization of static and dynamic sensor behavior agreed with numerical simulations, demonstrating a responsivity of 0.35 ± 0.07 fF/µN. Preliminary tests with cardiac tissues proved biocompatibility of the platform, as EHTs successfully formed and remained functional for at least 14 days
Original languageEnglish
Title of host publication22nd International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2023)
PublisherIEEE
Pages232-235
Number of pages4
ISBN (Electronic)978-4-88686-435-2
Publication statusPublished - 2023
EventTransducers 2023: 22nd International Conference on Solid-State Sensors, Actuators and Microsystems - Kyoto, Japan
Duration: 25 Jun 202329 Jun 2023

Conference

ConferenceTransducers 2023: 22nd International Conference on Solid-State Sensors, Actuators and Microsystems
Country/TerritoryJapan
CityKyoto
Period25/06/2329/06/23

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care
Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

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