Abstract
We present a novel capacitive displacement sensor integrated in an engineered heart tissue (EHT) platform to measure tissue contractile properties in-situ. Co-planar spiral capacitors were integrated into the elastomeric substrate underneath the two micropillars of a previously developed EHT platform. The capacitor plates are displaced by the tension and compression that occurs in the substrate when the micropillars bend under contractile tissue force. For a contraction force of ~200 µN, applied in the middle of pillar length, the expected change in base capacitance is in the aF range. Readout of such low capacitance changes was achieved using a commercial low-noise high-sensitivity device. Characterization of static and dynamic sensor behavior agreed with numerical simulations, demonstrating a responsivity of 0.35 ± 0.07 fF/µN. Preliminary tests with cardiac tissues proved biocompatibility of the platform, as EHTs successfully formed and remained functional for at least 14 days
Original language | English |
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Title of host publication | 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS 2023) |
Publisher | IEEE |
Pages | 232-235 |
Number of pages | 4 |
ISBN (Electronic) | 978-4-88686-435-2 |
Publication status | Published - 2023 |
Event | Transducers 2023: 22nd International Conference on Solid-State Sensors, Actuators and Microsystems - Kyoto, Japan Duration: 25 Jun 2023 → 29 Jun 2023 |
Conference
Conference | Transducers 2023: 22nd International Conference on Solid-State Sensors, Actuators and Microsystems |
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Country/Territory | Japan |
City | Kyoto |
Period | 25/06/23 → 29/06/23 |
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-careOtherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.