TY - JOUR
T1 - A model for cell migration in non-isotropic fibrin networks with an application to pancreatic tumor islets
AU - Chen, Jiao
AU - Weihs, Daphne
AU - Vermolen, Fred J.
PY - 2017
Y1 - 2017
N2 - Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response as well as other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic tumor islets. This migration is determined by the mechanical strain energy density as well as cytokines-driven chemotaxis. Cell displacement is modeled by solving a large system of ordinary stochastic differential equations where the stochastic parts result from random walk. The stochastic differential equations are solved by the use of the classical Euler–Maruyama method. In this paper, the influence of anisotropic stromal extracellular matrix in pancreatic tumor islets on T-lymphocytes migration in different immune systems is investigated. As a result, tumor peripheral stromal extracellular matrix impedes the immune response of T-lymphocytes through changing direction of their migration.
AB - Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response as well as other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic tumor islets. This migration is determined by the mechanical strain energy density as well as cytokines-driven chemotaxis. Cell displacement is modeled by solving a large system of ordinary stochastic differential equations where the stochastic parts result from random walk. The stochastic differential equations are solved by the use of the classical Euler–Maruyama method. In this paper, the influence of anisotropic stromal extracellular matrix in pancreatic tumor islets on T-lymphocytes migration in different immune systems is investigated. As a result, tumor peripheral stromal extracellular matrix impedes the immune response of T-lymphocytes through changing direction of their migration.
KW - Cell migration
KW - Cell-based model
KW - Pancreatic tumor islet
KW - Semi-stochastic model
KW - Stromal extracellular matrix
UR - http://www.scopus.com/inward/record.url?scp=85030860773&partnerID=8YFLogxK
UR - http://resolver.tudelft.nl/uuid:6d628385-3a08-4b6e-8c73-b2e4cde246be
U2 - 10.1007/s10237-017-0966-7
DO - 10.1007/s10237-017-0966-7
M3 - Article
AN - SCOPUS:85030860773
SN - 1617-7959
VL - 17 (2018)
SP - 367
EP - 386
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
IS - 2
ER -