A multiwell plate Organ-on-Chip (OOC) device for in-vitro cell culture stimulation and monitoring

N. Gaio, A. Waafi, M.L.H. Vlaming, E. Boschman, P. Dijkstra, O. Nacken, S.R. Braam, C. Boucsein, P. M. Sarro, R. Dekker

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

4 Citations (Scopus)


This work presents the first multi-well plate that allows for simultaneous mechanical stimulation and electrical monitoring of multiple in-vitro cell cultures in parallel. Each well of the plate is equipped with an Organ-on-Chip (OOC) device consisting of a stretchable micro-electrode array (MEA). For the first time, a film assisted molding (FAM) process was employed to embed an OOC into a multi well plate format packaging. The functionality of the MEA in the device was assessed with electrochemical impedance spectroscopy. Moreover, the biocompatibility of the plate was demonstrated with cardiomyocytes derived from human induced pluripotent stem cells (iPSC) cultured in the wells.

Original languageEnglish
Title of host publication2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
Place of PublicationPiscataway, NJ
Number of pages4
ISBN (Electronic)978-1-5386-4782-0
Publication statusPublished - 2018
EventMEMS 2018: 31st IEEE International Conference on Micro Electro Mechanical Systems - Belfast, United Kingdom
Duration: 21 Jan 201825 Jan 2018


ConferenceMEMS 2018
CountryUnited Kingdom
Internet address


  • Electrodes
  • Monitoring
  • Silicon
  • Packaging
  • Biomedical monitoring
  • Biomembranes
  • Impedance

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