Abstract
The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various ω-transaminases) catalyzed the enantio-specific reductive amination of the intermediate aldehydes and ketones. The system worked in a one-pot one-step fashion, whereas the productivity was significantly improved by switching to a one-pot two-step procedure. A wide range of aliphatic and aromatic compounds was transformed into the enantiomerically pure corresponding amines via the photo-enzymatic cascade.
Original language | English |
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Number of pages | 11 |
Journal | Catalysts |
Volume | 9 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Alcohol
- Cascade
- Photooxidation
- Reductive amination
- ω-transaminase