A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

A. Drozdz; U. Hanefeld; K. Szymańska; A. Jarzȩbski; A. Chrobok

doi:10.1016/j.catcom.2016.03.021

A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

A. Drozdz, U. Hanefeld, K. Szymańska, A. Jarzȩbski, A. Chrobok^*

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

15 Citations (Scopus)

Abstract

The new application of acyltransferase, isolated from Mycobacterium smegmatis for the chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones to lactones was demonstrated. Acyltransferase exhibited high activity, and high stability under harsh reaction conditions, like oxidation with 60% aq. H₂O₂ at 45°C. This paves the way to a novel robust chemo-enzymatic method for lactone synthesis with high yields.

Original language	English
Pages (from-to)	37-40
Number of pages	4
Journal	Catalysis Communications
Volume	81
DOIs	https://doi.org/10.1016/j.catcom.2016.03.021
Publication status	Published - 2016

Keywords

Acyltransferase
Baeyer-Villiger oxidation
Hydrogen peroxide
Lactones

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10.1016/j.catcom.2016.03.021

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abstract = "The new application of acyltransferase, isolated from Mycobacterium smegmatis for the chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones to lactones was demonstrated. Acyltransferase exhibited high activity, and high stability under harsh reaction conditions, like oxidation with 60% aq. H2O2 at 45°C. This paves the way to a novel robust chemo-enzymatic method for lactone synthesis with high yields.",

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AU - Drozdz, A.

AU - Hanefeld, U.

AU - Szymańska, K.

AU - Jarzȩbski, A.

AU - Chrobok, A.

PY - 2016

Y1 - 2016

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AB - The new application of acyltransferase, isolated from Mycobacterium smegmatis for the chemo-enzymatic Baeyer-Villiger oxidation of cyclic ketones to lactones was demonstrated. Acyltransferase exhibited high activity, and high stability under harsh reaction conditions, like oxidation with 60% aq. H2O2 at 45°C. This paves the way to a novel robust chemo-enzymatic method for lactone synthesis with high yields.

KW - Acyltransferase

KW - Baeyer-Villiger oxidation

KW - Hydrogen peroxide

KW - Lactones

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JO - Catalysis Communications

JF - Catalysis Communications

ER -

A robust chemo-enzymatic lactone synthesis using acyltransferase from Mycobacterium smegmatis

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Keywords

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