A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation

Virgilio Valente, Andreas Demosthenous, Richard Bayford

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)

Abstract

A significant problem with clinical deep brain stimulation (DBS) is the high variability of its efficacy and the frequency of side effects, related to the spreading of current beyond the anatomical target area. This is the result of the lack of control that current DBS systems offer on the shaping of the electric potential distribution around the electrode. This paper presents a stimulator ASIC with a tripolar current-steering output stage, aiming at achieving more selectivity and field shaping than current DBS systems. The ASIC was fabricated in a 0.35-μm CMOS technology occupying a core area of 0.71 mm 2. It consists of three current sourcing/sinking channels. It is capable of generating square and exponential-decay biphasic current pulses with five different time constants up to 28 ms and delivering up to 1.85 mA of cathodic current, in steps of 4 μA, from a 12 V power supply. Field shaping was validated by mapping the potential distribution when injecting current pulses through a multicontact DBS electrode in saline.

Original languageEnglish
Article number6080742
Pages (from-to)197-207
Number of pages11
JournalIEEE Transactions on Biomedical Circuits and Systems
Volume6
Issue number3
DOIs
Publication statusPublished - 6 Jun 2012
Externally publishedYes

Keywords

  • Current-steering
  • deep brain stimulation (DBS)
  • field shaping
  • finite element method (FEM)
  • integrated circuit
  • tripolar stimulation

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