Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

Babak Ghafaryasl, Koenraad A. Vermeer, J. Kalkman, Tom Callewaert, Johannes F. De Boer, Lucas J. Van Vliet

    Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

    1 Citation (Scopus)
    21 Downloads (Pure)

    Abstract

    The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.

    Original languageEnglish
    Title of host publicationProceedings of SPIE
    Subtitle of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII
    EditorsJoseph A. Izatt, James G. Fujimoto, Valery V. Tuchin
    Place of PublicationBellingham, WA, USA
    PublisherSPIE
    Number of pages6
    Volume10483
    ISBN (Electronic)9781510614512
    DOIs
    Publication statusPublished - 2018
    EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018 - San Francisco, United States
    Duration: 29 Jan 201831 Jan 2018

    Conference

    ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018
    CountryUnited States
    CitySan Francisco
    Period29/01/1831/01/18

    Bibliographical note

    Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

    Keywords

    • attenuation coefficient
    • beam-shape
    • Cramér-Rao lower bound
    • focus
    • OCT
    • point spread function
    • Rayleigh length

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