Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

Babak Ghafaryasl; Koenraad A. Vermeer; J. Kalkman; Tom Callewaert; Johannes F. De Boer; Lucas J. Van Vliet

doi:10.1117/12.2292002

Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

Babak Ghafaryasl, Koenraad A. Vermeer, J. Kalkman, Tom Callewaert, Johannes F. De Boer, Lucas J. Van Vliet

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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Abstract

The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.

Original language	English
Title of host publication	Proceedings of SPIE
Subtitle of host publication	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII
Editors	Joseph A. Izatt, James G. Fujimoto, Valery V. Tuchin
Place of Publication	Bellingham, WA, USA
Publisher	SPIE
Number of pages	6
Volume	10483
ISBN (Electronic)	9781510614512
DOIs	https://doi.org/10.1117/12.2292002
Publication status	Published - 2018
Event	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018 - San Francisco, United States Duration: 29 Jan 2018 → 31 Jan 2018

Conference

Conference	Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018
Country/Territory	United States
City	San Francisco
Period	29/01/18 → 31/01/18

Bibliographical note

Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

Keywords

attenuation coefficient
beam-shape
Cramér-Rao lower bound
focus
OCT
point spread function
Rayleigh length

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104832BFinal published version, 410 KB

Cite this

Ghafaryasl, B., Vermeer, K. A., Kalkman, J., Callewaert, T., De Boer, J. F., & Van Vliet, L. J. (2018). Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom. In J. A. Izatt, J. G. Fujimoto, & V. V. Tuchin (Eds.), Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII (Vol. 10483). Article 104832B SPIE. https://doi.org/10.1117/12.2292002

Ghafaryasl, Babak ; Vermeer, Koenraad A. ; Kalkman, J. et al. / Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom. Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII. editor / Joseph A. Izatt ; James G. Fujimoto ; Valery V. Tuchin. Vol. 10483 Bellingham, WA, USA : SPIE, 2018.

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title = "Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom",

abstract = "The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.",

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author = "Babak Ghafaryasl and Vermeer, {Koenraad A.} and J. Kalkman and Tom Callewaert and {De Boer}, {Johannes F.} and {Van Vliet}, {Lucas J.}",

note = "Green Open Access added to TU Delft Institutional Repository {\textquoteleft}You share, we take care!{\textquoteright} – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.; Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018 ; Conference date: 29-01-2018 Through 31-01-2018",

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Ghafaryasl, B, Vermeer, KA, Kalkman, J , Callewaert, T, De Boer, JF & Van Vliet, LJ 2018, Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom. in JA Izatt, JG Fujimoto & VV Tuchin (eds), Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII. vol. 10483, 104832B, SPIE, Bellingham, WA, USA, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018, San Francisco, United States, 29/01/18. https://doi.org/10.1117/12.2292002

Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom. / Ghafaryasl, Babak; Vermeer, Koenraad A.; Kalkman, J. et al.
Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII. ed. / Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin. Vol. 10483 Bellingham, WA, USA: SPIE, 2018. 104832B.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

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T1 - Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

AU - Ghafaryasl, Babak

AU - Vermeer, Koenraad A.

AU - Kalkman, J.

AU - Callewaert, Tom

AU - De Boer, Johannes F.

AU - Van Vliet, Lucas J.

N1 - Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.

PY - 2018

Y1 - 2018

N2 - The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.

AB - The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam.

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KW - Cramér-Rao lower bound

KW - focus

KW - OCT

KW - point spread function

KW - Rayleigh length

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AN - SCOPUS:85045676366

VL - 10483

BT - Proceedings of SPIE

A2 - Izatt, Joseph A.

A2 - Fujimoto, James G.

A2 - Tuchin, Valery V.

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Ghafaryasl B, Vermeer KA, Kalkman J , Callewaert T, De Boer JF, Van Vliet LJ. Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom. In Izatt JA, Fujimoto JG, Tuchin VV, editors, Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII. Vol. 10483. Bellingham, WA, USA: SPIE. 2018. 104832B doi: 10.1117/12.2292002

Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

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Keywords

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