Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

Gilbert Hangel*, Bárbara Schmitz-Abecassis, Joana Pinto, Nico Sollmann, Chih Hsien Tseng, Frans Vos, Esther Warnert, Marion Smits, Jan Petr, More Authors

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)
35 Downloads (Pure)


Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible clinical translation. This review describes current methods, limits, and applications of advanced MRI for the preoperative assessment of glioma, summarizing the level of clinical validation of different techniques. In this second part, we review magnetic resonance spectroscopy (MRS), chemical exchange saturation transfer (CEST), susceptibility-weighted imaging (SWI), MRI-PET, MR elastography (MRE), and MR-based radiomics applications. The first part of this review addresses dynamic susceptibility contrast (DSC) and dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL), diffusion-weighted MRI, vessel imaging, and magnetic resonance fingerprinting (MRF). Evidence Level: 3. Technical Efficacy: Stage 2.

Original languageEnglish
Pages (from-to)1676-1695
JournalJournal of Magnetic Resonance Imaging
Issue number6
Publication statusPublished - 2023


  • brain
  • contrasts
  • GliMR 2.0
  • glioma
  • level of clinical validation
  • preoperative


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