Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Amanda  Silva de Miranda; C.D.D.F. Milagre; F. Hollmann

doi:10.3389/fctls.2022.900554

Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Amanda Silva de Miranda, C.D.D.F. Milagre, F. Hollmann

BT/Biocatalysis

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Abstract

Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.

Original language	English
Number of pages	32
Journal	Frontiers in Catalysis
Volume	2
DOIs	https://doi.org/10.3389/fctls.2022.900554
Publication status	Published - 2022

Keywords

alcohol dehydrogenases (ADH)
oxidation reactions
Reduction reactions
enantioselective synthesis
alcohols
ketones
aldehydes
biocatalysis

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abstract = "Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.",

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T1 - Alcohol Dehydrogenases as Catalysts in Organic Synthesis

AU - Silva de Miranda, Amanda

AU - Milagre, C.D.D.F.

AU - Hollmann, F.

PY - 2022

Y1 - 2022

N2 - Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.

AB - Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.

KW - alcohol dehydrogenases (ADH)

KW - oxidation reactions

KW - Reduction reactions

KW - enantioselective synthesis

KW - alcohols

KW - ketones

KW - aldehydes

KW - biocatalysis

U2 - 10.3389/fctls.2022.900554

DO - 10.3389/fctls.2022.900554

M3 - Article

SN - 2673-7841

VL - 2

JO - Frontiers in Catalysis

JF - Frontiers in Catalysis

ER -

Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Abstract

Keywords

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