Alcohol Dehydrogenases as Catalysts in Organic Synthesis

Amanda Silva de Miranda, C.D.D.F. Milagre, F. Hollmann

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Abstract

Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this contribution is to provide the reader with a timely update on the state-of-the-art of ADH-catalysis. Mechanistic basics are presented together with practical information about the use of ADHs. Current concepts of ADH engineering and ADH reactions are critically discussed. Finally, this contribution highlights some prominent examples and future-pointing concepts.
Original languageEnglish
Number of pages32
JournalFrontiers in Catalysis
Volume2
DOIs
Publication statusPublished - 2022

Keywords

  • alcohol dehydrogenases (ADH)
  • oxidation reactions
  • Reduction reactions
  • enantioselective synthesis
  • alcohols
  • ketones
  • aldehydes
  • biocatalysis

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