Amino Aldehydes Revisited

Luuk Mestrom, M.P. Bracco Garcia, Ulf Hanefeld

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)

Abstract

The enzymatic oxidation of amino alcohols was studied to address the long-standing problem of product stability. Amino aldehydes, highly sought and unstable compounds, can be generated under mild conditions if they are immediately protected. Utilizing a range of alcohol dehydrogenases (ADHs) and semicarbazide as a scavenger, the enantioselective synthesis of protected amino aldehydes is possible. Glycerol dehydrogenase from Gluconobacter oxydans (GoGDH) displayed excellent enantioselectivity but limited substrate scope, whereas horse liver ADH catalyzed a broad range of conversions with low enantioselectivities.

Original languageEnglish
Pages (from-to)7019-7025
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number47
DOIs
Publication statusPublished - 22 Dec 2017

Keywords

  • Amino alcohols
  • Amino aldehydes
  • Biocatalysis
  • Enzymes
  • Oxidation

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