Abstract
The enzymatic oxidation of amino alcohols was studied to address the long-standing problem of product stability. Amino aldehydes, highly sought and unstable compounds, can be generated under mild conditions if they are immediately protected. Utilizing a range of alcohol dehydrogenases (ADHs) and semicarbazide as a scavenger, the enantioselective synthesis of protected amino aldehydes is possible. Glycerol dehydrogenase from Gluconobacter oxydans (GoGDH) displayed excellent enantioselectivity but limited substrate scope, whereas horse liver ADH catalyzed a broad range of conversions with low enantioselectivities.
Original language | English |
---|---|
Pages (from-to) | 7019-7025 |
Number of pages | 7 |
Journal | European Journal of Organic Chemistry |
Volume | 2017 |
Issue number | 47 |
DOIs | |
Publication status | Published - 22 Dec 2017 |
Keywords
- Amino alcohols
- Amino aldehydes
- Biocatalysis
- Enzymes
- Oxidation