An alginate-confined peroxygenase-CLEA for styrene epoxidation

Friederike E.H. Nintzel; Yinqi Wu; Matteo Planchestainer; Martin Held; Miguel Alcalde; Frank Hollmann

doi:10.1039/d1cc01868j

An alginate-confined peroxygenase-CLEA for styrene epoxidation

Friederike E.H. Nintzel, Yinqi Wu, Matteo Planchestainer, Martin Held, Miguel Alcalde, Frank Hollmann^*

^*Corresponding author for this work

BT/Biocatalysis

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Abstract

Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.

Original language	English
Pages (from-to)	5766-5769
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	47
DOIs	https://doi.org/10.1039/d1cc01868j
Publication status	Published - 2021

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10.1039/d1cc01868j

d1cc01868jFinal published version, 2.13 MBLicence: CC BY

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title = "An alginate-confined peroxygenase-CLEA for styrene epoxidation",

abstract = "Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM. ",

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AU - Nintzel, Friederike E.H.

AU - Wu, Yinqi

AU - Planchestainer, Matteo

AU - Held, Martin

AU - Alcalde, Miguel

AU - Hollmann, Frank

PY - 2021

Y1 - 2021

N2 - Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.

AB - Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.

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U2 - 10.1039/d1cc01868j

DO - 10.1039/d1cc01868j

M3 - Article

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AN - SCOPUS:85107814105

SN - 1359-7345

VL - 57

SP - 5766

EP - 5769

JO - Chemical Communications

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ER -

An alginate-confined peroxygenase-CLEA for styrene epoxidation

Abstract

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An alginate-confined peroxygenase-CLEA for styrene epoxidation

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Data underlying the publication: An alginate-confined peroxygenase-CLEA for styrene epoxidation

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