Abstract
In this paper, we present an equivalent circuit model that integrates a living myocardial slice (LMS) cultured on a microelectrode array (MEA) to effectively simulates a heart-on-a-chip (HoC) within Electronic Design Automation (EDA) software. The cardiac fiber model consists of cardiomyocytes interconnected by gap junctions to simulate the action potential (AP) conduction in the longitudinal direction. We systematically explored several parameters, including gap junction resistors, seal resistors, and electrode diameters, to assess their effects on local field potential (LFP). The model accuracy was validated through in vitro experiments using mouse LMS, confirming its potential for guiding HoC design in cardiac research.
| Original language | English |
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| Title of host publication | 2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024 |
| Publisher | IEEE |
| Number of pages | 5 |
| ISBN (Electronic) | 9798350354959 |
| DOIs | |
| Publication status | Published - 2024 |
| Event | 2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024 - Xi�an, China Duration: 24 Oct 2024 → 26 Oct 2024 |
Publication series
| Name | 2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024 |
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Conference
| Conference | 2024 IEEE Biomedical Circuits and Systems Conference, BioCAS 2024 |
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| Country/Territory | China |
| City | Xi�an |
| Period | 24/10/24 → 26/10/24 |
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-careOtherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Keywords
- action potential (AP)
- heart-on-a-chip (HoC)
- living myocardial slice (LMS)
- local field potential (LFP)
- microelectrode array (MEA)
- Verilog-A model