Association of polypharmacy and hyperpolypharmacy with frailty states: A systematic review and meta-analysis

Katie Palmer, Emanuele R. Villani, Davide L. Vetrano, Antonio Cherubini, Alfonso J.  Cruz‑Jentoft, Denis Curtin, Michael Denkinger, Marta  Gutiérrez‑Valencia, Adalsteinn Guðmundsson, Tischa van der Cammen, More Authors

Research output: Contribution to journalArticleScientificpeer-review

17 Citations (Scopus)
176 Downloads (Pure)

Abstract

Purpose: To investigate: (1) the cross-sectional association between polypharmacy, hyperpolypharmacy and presence of prefrailty or frailty; (2) the risk of incident prefrailty or frailty in persons with polypharmacy, and vice versa. Methods: A systematic review and meta-analysis was performed according to PRISMA guidelines. We searched PubMed, Web of Science, and Embase from 01/01/1998 to 5/2/2018. Pooled estimates were obtained through random effect models and Mantel–Haenszel weighting. Homogeneity was assessed with the I 2 statistic and publication bias with Egger’s and Begg’s tests. Results: Thirty-seven studies were included. The pooled proportion of polypharmacy in persons with prefrailty and frailty was 47% (95% CI 33–61) and 59% (95% CI 42–76), respectively. Increased odds ratio of polypharmacy were seen for prefrail (pooled OR = 1.52; 95% CI 1.32–1.79) and frail persons (pooled OR = 2.62, 95% CI 1.81–3.79). Hyperpolypharmacy was also increased in prefrail (OR = 1.95; 95% CI 1.41–2.70) and frail (OR = 6.57; 95% CI 9.57–10.48) persons compared to robust persons. Only seven longitudinal studies reported data on the risk of either incident prefrailty or frailty in persons with baseline polypharmacy. A significant higher odds of developing prefrailty was found in robust persons with polypharmacy (pooled OR = 1.30; 95% CI 1.12–1.51). We found no papers investigating polypharmacy incidence in persons with prefrailty/frailty. Conclusions: Polypharmacy is common in prefrail and frail persons, and these individuals are also more likely to be on extreme drug regimens, i.e. hyperpolypharmacy, than robust older persons. More research is needed to investigate the causal relationship between polypharmacy and frailty syndromes, thereby identifying ways to jointly reduce drug burden and prefrailty/frailty in these individuals. Prospero registration number: CRD42018104756.

Original languageEnglish
Pages (from-to)9-36
Number of pages28
JournalEuropean Geriatric Medicine
Volume10
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • Frail
  • Prefrail
  • Polypharmacy
  • Drugs
  • Ageing
  • Medications
  • Hyperpolypharmacy

Fingerprint Dive into the research topics of 'Association of polypharmacy and hyperpolypharmacy with frailty states: A systematic review and meta-analysis'. Together they form a unique fingerprint.

  • Cite this

    Palmer, K., Villani, ER., Vetrano, DL., Cherubini, A., Cruz‑Jentoft, AJ. ., Curtin, D., Denkinger, M., Gutiérrez‑Valencia, M., Guðmundsson, A., van der Cammen, T., & More Authors (2019). Association of polypharmacy and hyperpolypharmacy with frailty states: A systematic review and meta-analysis. European Geriatric Medicine, 10(1), 9-36. https://doi.org/10.1007/s41999-018-0124-5