autoTICI: Automatic Brain Tissue Reperfusion Scoring on 2D DSA Images of Acute Ischemic Stroke Patients

Ruisheng Su, Sandra A.P. Cornelissen, Matthijs Van der Sluijs, Adriaan C.G.M. Van Es, Wim H. Van Zwam, Diederik W.J. Dippel, Wiro J. Niessen, Aad Van der Lugt, Theo Van Walsum, More Authors

Research output: Contribution to journalArticleScientificpeer-review

19 Citations (Scopus)


The Thrombolysis in Cerebral Infarction (TICI) score is an important metric for reperfusion therapy assessment in acute ischemic stroke. It is commonly used as a technical outcome measure after endovascular treatment (EVT). Existing TICI scores are defined in coarse ordinal grades based on visual inspection, leading to inter-and intra-observer variation. In this work, we present autoTICI, an automatic and quantitative TICI scoring method. First, each digital subtraction angiography (DSA) acquisition is separated into four phases (non-contrast, arterial, parenchymal and venous phase) using a multi-path convolutional neural network (CNN), which exploits spatio-temporal features. The network also incorporates sequence level label dependencies in the form of a state-transition matrix. Next, a minimum intensity map (MINIP) is computed using the motion corrected arterial and parenchymal frames. On the MINIP image, vessel, perfusion and background pixels are segmented. Finally, we quantify the autoTICI score as the ratio of reperfused pixels after EVT. On a routinely acquired multi-center dataset, the proposed autoTICI shows good correlation with the extended TICI (eTICI) reference with an average area under the curve (AUC) score of 0.81. The AUC score is 0.90 with respect to the dichotomized eTICI. In terms of clinical outcome prediction, we demonstrate that autoTICI is overall comparable to eTICI.

Original languageEnglish
Article number9420702
Pages (from-to)2380-2391
Number of pages12
JournalIEEE Transactions on Medical Imaging
Issue number9
Publication statusPublished - 2021


  • DSA
  • MR CLEAN Registry
  • Stroke
  • autoTICI
  • brain tissue perfusion
  • deep learning
  • phase classification


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