Balancing the ventricular outputs of pulsatile total artificial hearts

Oskar J. Gülcher, Annemijn Vis*, Mathias Peirlinck, Jolanda Kluin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Background: Maintaining balanced left and right cardiac outputs in a total artificial heart (TAH) is challenging due to the need for continuous adaptation to changing hemodynamic conditions. Proper balance in ventricular outputs of the left and right ventricles requires a preload-sensitive response and mechanisms to address the higher volumetric efficiency of the right ventricle. Methods: This review provides a comprehensive overview of various methods used to balance left and right ventricular outputs in pulsatile total artificial hearts, categorized based on their actuation mechanism. Results: Reported strategies include incorporating compliant materials and/or air cushions inside the ventricles, employing active control mechanisms to regulate ventricular filling state, and utilizing various shunts (such as hydraulic or intra-atrial shunts). Furthermore, reducing right ventricular stroke volume compared to the left often serves to balance the ventricular outputs. Individually controlled actuation of both ventricles in a pulsatile TAH seems to be the simplest and most effective way to achieve proper preload sensitivity and left–right output balance. Pneumatically actuated TAHs have the advantage to respond passively to preload changes. Conclusion: Therefore, a pneumatic TAH that comprises two individually actuated ventricles appears to be a more desirable option—both in terms of simplicity and efficacy—to respond to changing hemodynamic conditions.

Original languageEnglish
Pages (from-to)1809-1817
Number of pages9
JournalArtificial Organs
Volume47
Issue number12
DOIs
Publication statusPublished - 2023

Keywords

  • heart-assist devices
  • left–right balance
  • preload sensitivity
  • review

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