Bio-inspired supramolecular materials by orthogonal self-assembly of hydrogelators and phospholipids

J. Boekhoven, A. M. Brizard, M. C A Stuart, L. Florusse, G. Raffy, A. Del Guerzo, J. H. Van Esch*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

42 Citations (Scopus)
39 Downloads (Pure)


The orthogonal self-assembly of multiple components is a powerful strategy towards the formation of complex biomimetic architectures, but so far the rules for designing such systems are unclear. Here we show how to identify orthogonal self-assembly at the supramolecular level and describe guidelines to achieve self-sorting in self-assembled mixed systems. By investigating multicomponent self-assembled systems consisting of low molecular weight gelators and phospholipids, both at a molecular and a supramolecular level, we found that orthogonal self-assembly can only take place if the entities assemble via a strong and distinct set of interactions. The resulting supramolecular architectures consist of fibrillar networks that coexist with liposomes and thereby provide additional levels of compartmentalization and enhanced stability as compared to self-assembled systems of gelators or phospholipids alone.

Original languageEnglish
Pages (from-to)6021-6031
Number of pages11
JournalChemical Science
Issue number9
Publication statusPublished - 2016


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