Biocatalysis engineering: the big picture

Roger Sheldon, Pedro Cherando Pereira

Research output: Contribution to journalArticleScientificpeer-review

193 Citations (Scopus)


In this tutorial review we describe a holistic approach to the invention, development and optimisation of biotransformations utilising isolated enzymes. Increasing attention to applied biocatalysis is motivated by its numerous economic and environmental benefits. Biocatalysis engineering concerns the development of enzymatic systems as a whole, which entails engineering its different components: substrate engineering, medium engineering, protein (enzyme) engineering, biocatalyst (formulation) engineering, biocatalytic cascade engineering and reactor engineering.
Original languageEnglish
Pages (from-to)2678-2691
Number of pages14
JournalChemical Society Reviews
Publication statusPublished - 13 Mar 2017


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