Biocatalytic Oxidation Reactions: A Chemist's Perspective

Jia Jia Dong, Elena Fernandez Fueyo, Frank Hollmann, Caroline Paul, Milja Pesic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang

Research output: Contribution to journalArticleScientificpeer-review

141 Citations (Scopus)
134 Downloads (Pure)


Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non‐activated C−H bonds. For many of these reactions, no “classical” chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes based on a more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. In this Review, we critically summarise the most important recent developments in the field of biocatalytic oxidation chemistry and identify the most pressing bottlenecks as well as promising solutions.
Original languageEnglish
Pages (from-to)9238-9261
JournalAngewandte Chemie (International Edition)
Issue number30
Publication statusPublished - 2018


  • German Edition :D OI:10.1002/ange.201800343 Bioc atalys is International Edition :DOI:10.1002/anie.201800343 Biocatalytic Oxidation Reactions :AChemist s Perspectiv e JiaJia Dong ,Elena Fern μ ndez-Fueyo ,Frank Hollmann,* Caroline E. Paul, Milja Pesic,Sandy Schmidt, Yonghua Wang,Sabry Younes,and Baeyer–Villiger oxidation
  • biocatalysis
  • halogenation
  • oxidation
  • oxyfunctionalisation

Fingerprint Dive into the research topics of 'Biocatalytic Oxidation Reactions: A Chemist's Perspective'. Together they form a unique fingerprint.

Cite this