Biocatalytic synthesis of lactones and lactams

Frank Hollmann, Selin Kara, Diederik J. Opperman, Yonghua Wang

Research output: Contribution to journalArticleScientificpeer-review

11 Citations (Scopus)
42 Downloads (Pure)


Cyclic esters and amides (lactones and lactams) are important active ingredients and polymer building blocks. In recent years, numerous biocatalytic methods for their preparation have been developed including enzymatic and chemoenzymatic Baeyer–Villiger oxidations, oxidative lactonisation of diols, and reductive lactonisation and lactamisation of ketoesters. The current state of the art of these methods is reviewed.

Original languageEnglish
Pages (from-to)3601=3610
JournalChemistry - An Asian Journal
Issue number23
Publication statusPublished - 2018


  • Baeyer–Villiger oxidation
  • biocatalysis
  • lactams
  • lactones
  • oxidative Lactonisation

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