Brain transcriptome atlases: A computational perspective

Research output: Contribution to journalArticleScientificpeer-review

9 Citations (Scopus)
25 Downloads (Pure)

Abstract

The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms which define neuronal identities, neuroanatomy, and patterns of connectivity. Despite the immense effort put into generating such atlases, to answer fundamental questions in neuroscience, an even greater effort is needed to develop methods to probe the resulting high-dimensional multivariate data. We provide a comprehensive overview of the various computational methods used to analyze brain transcriptome atlases.
Original languageEnglish
Pages (from-to)1557-1580
Number of pages24
JournalBrain Structure and Function
DOIs
Publication statusPublished - 2017

Keywords

  • Brain atlases
  • Gene expression
  • Co-expression
  • Omics integration
  • Imaging genetics

Fingerprint Dive into the research topics of 'Brain transcriptome atlases: A computational perspective'. Together they form a unique fingerprint.

Cite this