TY - JOUR
T1 - Brain transcriptome atlases
T2 - A computational perspective
AU - Mahfouz, Ahmed
AU - Huisman, Sjoerd M.H.
AU - Lelieveldt, Boudewijn P.F.
AU - Reinders, Marcel J.T.
PY - 2017
Y1 - 2017
N2 - The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms which define neuronal identities, neuroanatomy, and patterns of connectivity. Despite the immense effort put into generating such atlases, to answer fundamental questions in neuroscience, an even greater effort is needed to develop methods to probe the resulting high-dimensional multivariate data. We provide a comprehensive overview of the various computational methods used to analyze brain transcriptome atlases.
AB - The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms which define neuronal identities, neuroanatomy, and patterns of connectivity. Despite the immense effort put into generating such atlases, to answer fundamental questions in neuroscience, an even greater effort is needed to develop methods to probe the resulting high-dimensional multivariate data. We provide a comprehensive overview of the various computational methods used to analyze brain transcriptome atlases.
KW - Brain atlases
KW - Gene expression
KW - Co-expression
KW - Omics integration
KW - Imaging genetics
UR - http://resolver.tudelft.nl/uuid:28e71809-4b3b-494d-b951-9323d0b6fa1a
U2 - 10.1007/s00429-016-1338-2
DO - 10.1007/s00429-016-1338-2
M3 - Article
SN - 1863-2653
SP - 1557
EP - 1580
JO - Brain Structure and Function
JF - Brain Structure and Function
ER -