TY - JOUR
T1 - Building blocks for a European Organ-on-Chip roadmap
AU - Mastrangeli, Massimo
AU - Millet, Sylvie
AU - Mummery, Christine
AU - Loskill, Peter
AU - Braeken, Dries
AU - Eberle, Wolfgang
AU - Cipriano, Madalena
AU - Fernandez, Luis
AU - Graef, Mart
AU - Gidrol, Xavier
AU - Picollet-D'Hahan, Nathalie
AU - van Meer, Berend
AU - Ochoa, Ignacio
AU - Schutte, Mieke
AU - van den Eijnden-van Raaij, Janny
N1 - green
PY - 2019/7/19
Y1 - 2019/7/19
N2 - This paper summarizes the outcome of the Organ-on-Chip (OoC) ORCHID Strategy workshop (Leiden, the Netherlands, 17 January 2019) intended to establish a European OoC roadmap through expert discussions, conclusions and recommendations. The workshop identified six specific building blocks for the OoC roadmap: (1) application, (2) specification, (3) qualification, (4) standardization, (5) production and upscaling, and (6) adoption. Complementary aspects relating to ethics and communication were also addressed. Priorities, methods and targets for the roadmap were proposed for each building block. General consensus was reached on the potential contribution of the newly founded European Organ-on-Chip Society (EUROoCS), which could facilitate deployment of each block. EUROoCS would ideally initiate and catalyze dialogue between OoC developers, end users and regulators. The dialogue should address qualification, open technology platforms, standardization and implementation of OoC technology, as well as ethical aspects of human tissue mimics, training the next generation of OoC researchers, dissemination and communication.
AB - This paper summarizes the outcome of the Organ-on-Chip (OoC) ORCHID Strategy workshop (Leiden, the Netherlands, 17 January 2019) intended to establish a European OoC roadmap through expert discussions, conclusions and recommendations. The workshop identified six specific building blocks for the OoC roadmap: (1) application, (2) specification, (3) qualification, (4) standardization, (5) production and upscaling, and (6) adoption. Complementary aspects relating to ethics and communication were also addressed. Priorities, methods and targets for the roadmap were proposed for each building block. General consensus was reached on the potential contribution of the newly founded European Organ-on-Chip Society (EUROoCS), which could facilitate deployment of each block. EUROoCS would ideally initiate and catalyze dialogue between OoC developers, end users and regulators. The dialogue should address qualification, open technology platforms, standardization and implementation of OoC technology, as well as ethical aspects of human tissue mimics, training the next generation of OoC researchers, dissemination and communication.
KW - organ-on-chip
KW - microphysiological systems
KW - roadmap
KW - qualification
KW - adoption
KW - Stem cells
KW - organoids
KW - open technology platform
UR - http://www.scopus.com/inward/record.url?scp=85077222245&partnerID=8YFLogxK
U2 - 10.14573/altex.1905221
DO - 10.14573/altex.1905221
M3 - Article
SN - 1868-596X
VL - 36
SP - 481
EP - 492
JO - ALTEX - Alternatives to Animal Experimentation
JF - ALTEX - Alternatives to Animal Experimentation
IS - 3
ER -