Cascading g-C3N4 and Peroxygenases for Selective Oxyfunctionalization Reactions

Morten M.C.H. Van Schie, Wuyuan Zhang, Florian Tieves, Da Som Choi, Chan Beum Park, Bastien O. Burek, Jonathan Z. Bloh, Isabel W.C.E. Arends, Caroline E. Paul, Miguel Alcalde, Frank Hollmann

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25 Citations (Scopus)
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Peroxygenases are very interesting catalysts for specific oxyfunctionalization chemistry. Instead of relying on complicated electron transport chains, they rely on simple hydrogen peroxide as the stoichiometric oxidant. Their poor robustness against H2O2 can be addressed via in situ generation of H2O2. Here we report that simple graphitic carbon nitride (g-C3N4) is a promising photocatalyst to drive peroxygenase-catalyzed hydroxylation reactions. The system has been characterized by outlining not only its scope but also its current limitations. In particular, spatial separation of the photocatalyst from the enzyme is shown as a solution to circumvent the undesired inactivation of the biocatalyst. Overall, very promising turnover numbers of the biocatalyst of more than 60.000 have been achieved.

Original languageEnglish
Pages (from-to)7409-7417
JournalACS Catalysis
Issue number8
Publication statusPublished - 2019


  • cascade reactions
  • enzyme catalysis
  • oxidation
  • oxyfunctionalization
  • photocatalysis


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