Catching DNA with hoops-biophysical approaches to clarify the mechanism of SMC proteins

Jorine Eeftens; Cees Dekker

doi:10.1038/nsmb.3507

Catching DNA with hoops-biophysical approaches to clarify the mechanism of SMC proteins

Jorine Eeftens, Cees Dekker

BN/Cees Dekker Lab

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

117 Downloads (Pure)

Abstract

Structural maintenance of chromosome (SMC) complexes are central regulators of chromosome architecture that are essential in all domains of life. For decades, the structural biology field has been debating how these conserved protein complexes use their intricate ring-like structures to structurally organize DNA. Here, we review the contributions of single-molecule biophysical approaches to resolving the molecular mechanism of SMC protein function.

Original language	English
Pages (from-to)	1012-1020
Number of pages	9
Journal	Nature Structural and Molecular Biology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1038/nsmb.3507
Publication status	Published - 7 Dec 2017

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EeftensDekker_Revised_Catching DNA with hoopsAccepted author manuscript, 5.46 MB

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Catching DNA with hoops-biophysical approaches to clarify the mechanism of SMC proteins

Abstract

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