Chemoenzymatic Halocyclization of γ,δ-Unsaturated Carboxylic Acids and Alcohols

Sabry H.H. Younes, Florian Tieves, Dongming Lan, Yonghua Wang, Philipp Süss, Henrike Brundiek, Ron Wever, Frank Hollmann*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

21 Citations (Scopus)
106 Downloads (Pure)


A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V-dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the biocatalyst.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
Issue number1
Publication statusPublished - 2019


  • biocatalysis
  • enzymes
  • etherification
  • haloperoxidases
  • lactones


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