Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Georg T. Höfler, Andrada But, Sabry H.H. Younes, Ron Wever, Caroline E. Paul, Isabel W.C.E. Arends, Frank Hollmann

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
39 Downloads (Pure)


The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.

Original languageEnglish
Pages (from-to)2602-2607
JournalACS Sustainable Chemistry and Engineering
Issue number7
Publication statusPublished - 2020


  • Chemoenzymatic halocyclization
  • Haloperoxidase
  • Preparative scale

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