Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Georg T. Höfler; Andrada But; Sabry H.H. Younes; Ron Wever; Caroline E. Paul; Isabel W.C.E. Arends; Frank Hollmann

doi:10.1021/acssuschemeng.9b07494

Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Georg T. Höfler, Andrada But, Sabry H.H. Younes, Ron Wever, Caroline E. Paul, Isabel W.C.E. Arends, Frank Hollmann^*

^*Corresponding author for this work

BT/Biocatalysis

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.

Original language	English
Pages (from-to)	2602-2607
Number of pages	6
Journal	ACS Sustainable Chemistry and Engineering
Volume	8
Issue number	7
DOIs	https://doi.org/10.1021/acssuschemeng.9b07494
Publication status	Published - 2020

Keywords

Chemoenzymatic halocyclization
Haloperoxidase
Preparative scale

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acssuschemeng.9b07494

acssuschemeng.9b07494Final published version, 1.05 MBLicence: CC BY-NC-ND

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title = "Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale",

abstract = "The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.",

keywords = "Chemoenzymatic halocyclization, Haloperoxidase, Preparative scale",

author = "H{\"o}fler, {Georg T.} and Andrada But and Younes, {Sabry H.H.} and Ron Wever and Paul, {Caroline E.} and Arends, {Isabel W.C.E.} and Frank Hollmann",

year = "2020",

doi = "10.1021/acssuschemeng.9b07494",

language = "English",

volume = "8",

pages = "2602--2607",

journal = "ACS Sustainable Chemistry and Engineering",

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publisher = "American Chemical Society (ACS)",

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T1 - Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

AU - Höfler, Georg T.

AU - But, Andrada

AU - Younes, Sabry H.H.

AU - Wever, Ron

AU - Paul, Caroline E.

AU - Arends, Isabel W.C.E.

AU - Hollmann, Frank

PY - 2020

Y1 - 2020

N2 - The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.

AB - The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.

KW - Chemoenzymatic halocyclization

KW - Haloperoxidase

KW - Preparative scale

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U2 - 10.1021/acssuschemeng.9b07494

DO - 10.1021/acssuschemeng.9b07494

M3 - Article

SN - 2168-0485

VL - 8

SP - 2602

EP - 2607

JO - ACS Sustainable Chemistry and Engineering

JF - ACS Sustainable Chemistry and Engineering

IS - 7

ER -

Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Abstract

Keywords

UN SDGs

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