Chemoenzymatic intermolecular haloether synthesis

Shaohang Chen, Jiaan Zhang, Zhigang Zeng*, Zongjie Dai, Qinhong Wang, Ron Wever, Frank Hollmann, Wuyuan Zhang

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review


A chemoenzymatic method for the synthesis of haloethers is presented. A combination of enzymatic hypohalite synthesis with spontaneous oxidation of alkenes and nucleophilic attack by various alcohols enabled the synthesis of a wide range of haloethers. The reaction system has been characterised and current imitations have been worked out. In the present, aqueous reaction system, hydroxyhalide formation represents the main undesired side reaction. Nevertheless, semi-preparative scale synthesis of a range of haloethers is demonstrated.

Original languageEnglish
Article number112061
JournalMolecular Catalysis
Publication statusPublished - Jan 2022


  • Chemoenzymatic synthesis
  • Ether synthesis
  • Haloetherification
  • Vanadium chloroperoxidase


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