CMOS Image Sensor for Lateral Flow Immunoassay Readers

Evdokia Pilavaki, Virgilio Valente, Andreas Demosthenous

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)
19 Downloads (Pure)

Abstract

Point-of-care systems for the detection of infectious diseases are in great demand especially in developing countries. Lateral flow immunoassays are considered ideal biosensors for point-of-care diagnostics due to their numerous advantages. However, to quantify their results a low power, robust electronic reader is needed. A low power CMOS image sensor is presented that can be used in quantitative lateral flow immunoassay readers. It uses a single low power processing capacitive transimpedance amplifier architecture which includes noise cancellation. A chip containing 4 × 64 pixels was fabricated in CMOS 0.35-μm technology. With uniform illumination at 525 nm and 67 frames per second the chip has 1.9 mVrms total output referred noise and a total power consumption of 21 μW. In tests with lateral flow immunoassays the chip detected concentrations of influenza A nucleoprotein from 0.5 ng/mL to 200 ng/mL.

Original languageEnglish
Pages (from-to)1405-1409
Number of pages5
JournalIEEE Transactions on Circuits and Systems II: Express Briefs
Volume62
Issue number10
DOIs
Publication statusPublished - 2018

Keywords

  • capacitive transimpedance amplifier
  • CMOS image sensor
  • Immune system
  • Influenza
  • lateral flow immunoassays
  • Logic gates
  • Noise cancellation
  • Photoconductivity
  • point-of-care.
  • Semiconductor device measurement
  • Switches

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