Abstract
Point-of-care systems for the detection of infectious diseases are in great demand especially in developing countries. Lateral flow immunoassays are considered ideal biosensors for point-of-care diagnostics due to their numerous advantages. However, to quantify their results a low power, robust electronic reader is needed. A low power CMOS image sensor is presented that can be used in quantitative lateral flow immunoassay readers. It uses a single low power processing capacitive transimpedance amplifier architecture which includes noise cancellation. A chip containing 4 × 64 pixels was fabricated in CMOS 0.35-μm technology. With uniform illumination at 525 nm and 67 frames per second the chip has 1.9 mVrms total output referred noise and a total power consumption of 21 μW. In tests with lateral flow immunoassays the chip detected concentrations of influenza A nucleoprotein from 0.5 ng/mL to 200 ng/mL.
Original language | English |
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Pages (from-to) | 1405-1409 |
Number of pages | 5 |
Journal | IEEE Transactions on Circuits and Systems II: Express Briefs |
Volume | 62 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- capacitive transimpedance amplifier
- CMOS image sensor
- Immune system
- Influenza
- lateral flow immunoassays
- Logic gates
- Noise cancellation
- Photoconductivity
- point-of-care.
- Semiconductor device measurement
- Switches