Combined optical sizing and acoustical characterization of single freely-floating microbubbles

Ying Luan, Guillaume Renaud, Jason L. Raymond, Tim Segers, Guillaume Lajoinie, Robert Beurskens, Frits Mastik, Tom J A Kokhuis, Antonius F W Van Der Steen, Michel Versluis, Nico De Jong

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    Abstract

    In this study we present a combined optical sizing and acoustical characterization technique for the study of the dynamics of single freely-floating ultrasound contrast agent microbubbles exposed to long burst ultrasound excitations up to the milliseconds range. A co-axial flow device was used to position individual microbubbles on a streamline within the confocal region of three ultrasound transducers and a high-resolution microscope objective. Bright-field images of microbubbles passing through the confocal region were captured using a high-speed camera synchronized to the acoustical data acquisition to assess the microbubble response to a 1-MHz ultrasound burst. Nonlinear bubble vibrations were identified at a driving pressure as low as 50 kPa. The results demonstrate good agreement with numerical simulations based on the shell-buckling model proposed by Marmottant et al. [J. Acoust. Soc. Am. 118, 3499-3505 (2005)]. The system demonstrates the potential for a high-throughput in vitro characterization of individual microbubbles.

    Original languageEnglish
    Article number234104
    JournalApplied Physics Letters
    Volume109
    Issue number23
    DOIs
    Publication statusPublished - 7 Dec 2016

    Keywords

    • Ultranonography
    • Bubble dynamics
    • Nonlinear dynamics
    • Vibration testing
    • Cameras

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