TY - JOUR
T1 - Comparison between a phenomenological approach and a morphoelasticity approach regarding the displacement of extracellular matrix
AU - Peng, Q.
AU - Gorter, W.S.
AU - Vermolen, F.J.
PY - 2022
Y1 - 2022
N2 - Plastic (permanent) deformations were earlier, modeled by a phenomenological model in Peng and Vermolen (Biomech Model Mechanobiol 19(6):2525–2551, 2020). In this manusctipt, we consider a more physics-based formulation that is based on morphoelasticity. We firstly introduce the morphoelasticity approach and investigate the impact of various input variables on the output parameters by sensitivity analysis. A comparison of both model formulations shows that both models give similar computational results. Furthermore, we carry out Monte Carlo simulations of the skin contraction model containing the morphoelasticity approach. Most statistical correlations from the two models are similar, however, the impact of the collagen density on the severeness of contraction is larger for the morphoelasticity model than for the phenomenological model.
AB - Plastic (permanent) deformations were earlier, modeled by a phenomenological model in Peng and Vermolen (Biomech Model Mechanobiol 19(6):2525–2551, 2020). In this manusctipt, we consider a more physics-based formulation that is based on morphoelasticity. We firstly introduce the morphoelasticity approach and investigate the impact of various input variables on the output parameters by sensitivity analysis. A comparison of both model formulations shows that both models give similar computational results. Furthermore, we carry out Monte Carlo simulations of the skin contraction model containing the morphoelasticity approach. Most statistical correlations from the two models are similar, however, the impact of the collagen density on the severeness of contraction is larger for the morphoelasticity model than for the phenomenological model.
KW - Force balance
KW - Mechanics
KW - Morphoelasticity
KW - Phenomenological approach
KW - Skin contractions
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85128054675&partnerID=8YFLogxK
U2 - 10.1007/s10237-022-01568-3
DO - 10.1007/s10237-022-01568-3
M3 - Article
C2 - 35403944
AN - SCOPUS:85128054675
SN - 1617-7959
VL - 21
SP - 919
EP - 935
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
IS - 3
ER -