Computational design of patient-specific orthopedic implants: from micro-architected materials to shape-matching geometry

Research output: ThesisDissertation (TU Delft)

46 Downloads (Pure)

Abstract

Background: Despite over a century’s worth of technical improvements, the longterm survivability associated with orthopedic implants continues to fall short. In contrast to earlier designs, implant failure is no longer caused by structural failure of the implant itself. Rather, it results from the implant’s long-term detrimental effects on the surrounding bone tissue. Over time, changes in mechanical loading conditions induce a reduction in bone density, increasing the risk of fracture, and destabilizing the bone-implant interface. The mechanisms which drive peri-prosthetic bone loss are complicated and inter-related. Add to this the unique morphological variations among patients, and an optimal one-size-fits-all solution seems unlikely.....
Original languageEnglish
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Zadpoor, A.A., Supervisor
  • Wu, J., Supervisor
Award date12 Mar 2024
Print ISBNs978-94-6384-552-6
DOIs
Publication statusPublished - 2024

Keywords

  • Computational design
  • topology optimization
  • orthopedic implants
  • patient-specific
  • micro-architected materials
  • bone remodelling
  • bone preservation
  • osseointegration
  • insertability

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