TY - JOUR
T1 - Concurrent white and gray matter degeneration of disease-specific networks in early-stage Alzheimer's disease and behavioral variant frontotemporal dementia
AU - Steketee, Rebecca M E
AU - Meijboom, Rozanna
AU - de Groot, Marius
AU - Bron, Esther E.
AU - Niessen, Wiro J.
AU - van der Lugt, Aad
AU - van Swieten, John C.
AU - Smits, Marion
PY - 2016
Y1 - 2016
N2 - This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.
AB - This study investigates regional coherence between white matter (WM) microstructure and gray matter (GM) volume and perfusion measures in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) using a correlational approach. WM-GM coherence, compared with controls, was stronger between cingulum WM and frontotemporal GM in AD, and temporoparietal GM in bvFTD. In addition, in AD compared with controls, coherence was stronger between inferior fronto-occipital fasciculus WM microstructure and occipital GM perfusion. In this first study assessing regional WM-GM coherence in AD and bvFTD, we show that WM microstructure and GM volume and perfusion measures are coherent, particularly in regions implicated in AD and bvFTD pathology. This indicates concurrent degeneration in disease-specific networks. Our methodology allows for the detection of incipient abnormalities that go undetected in conventional between-group analyses.
KW - Alzheimer's disease
KW - Arterial spin labeling
KW - Behavioral variant frontotemporal dementia
KW - Diffusion tensor imaging
KW - Structural MRI
UR - http://www.scopus.com/inward/record.url?scp=84966430598&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2016.03.031
DO - 10.1016/j.neurobiolaging.2016.03.031
M3 - Article
AN - SCOPUS:84966430598
SN - 0197-4580
VL - 43
SP - 119
EP - 128
JO - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
JF - Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
ER -