Construction of correlation networks with explicit time-slices using time-lagged, variable interval standard and partial correlation coefficients

W Meuleman, MCM Welten, FJ Verbeek

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

Abstract

Theconstructionofgeneregulatorymodelsfrommicroarraytime-seriesdatahasreceivedmuchattention.Hereweproposeamethodthatextendsstandardcorrelationnetworkstoincorporateexplicittimeslices.Themethodisappliedtoatime-seriesdatasetofastudyongeneexpressioninthedevelopmentalphaseofzebra¿sh.Resultsshowthatthemethodisabletodistinguishrealrelationsbetweengenesfromthedata.Theserelationsareexplicitlyplacedintime,allowingforabetterunderstandingofgeneregulation.ThemethodanddatanormalisationprocedurehavebeenimplementedusingtheRstatisticallanguageandareavailablefromhttp://zebrafish.liacs.nl/supplements.html.
Original languageUndefined/Unknown
Title of host publicationComputational Life Sciences II
EditorsMR Berthold, R. Glen, I. Fischer
Place of PublicationBerlin-Heidelberg
PublisherSpringer
Pages236-246
Number of pages11
ISBN (Print)3-540-45767-4
Publication statusPublished - 2006
EventSecond International Symposium, CompLife 2006, Cambridge, UK - Berlin-Heidelberg
Duration: 27 Sep 200629 Sep 2006

Publication series

Name
PublisherSpringer
Name
Volume4216

Conference

ConferenceSecond International Symposium, CompLife 2006, Cambridge, UK
Period27/09/0629/09/06

Keywords

  • conference contrib. refereed
  • Conf.proc. > 3 pag

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