Correlating 3D light to 3D electron microscopy for systems biology

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    Abstract

    Whilst a ‘resolution revolution’ has taken place at the macromolecular scale in both electron microscopy and light microscopy, a ‘volume revolution’ has taken place at the tissue and organism level in both imaging modalities. At both ends of the scale – resolution and volume – there are concerted efforts to link the information from light and electron microscopes through correlative workflows to link structure to function. Here, we consider the status and potential of correlative imaging in the volume domain (3D CLEM).
    Original languageEnglish
    Pages (from-to)49-55
    JournalCurrent Opinion in Biomedical Engineering
    Volume3
    DOIs
    Publication statusPublished - 15 Nov 2017

    Keywords

    • Correlative microscopy
    • 3D CLEM
    • Large scale imaging
    • Volume electron microscopy
    • Ultrastructure
    • Systems biology

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