Cross-validated Cox regression on microarray gene expression data

HC van Houwelingen, T Bruinsma, AAM Hart, LJ van 't Veer, LFA Wessels

Research output: Contribution to journalArticleScientificpeer-review

128 Citations (Scopus)


This paper describes how penalized Cox regression, in combination with cross-validated partial likelihood can be employed to obtain reliable survival prediction models for high dimensional microarray data. The suggested procedure is demonstrated on a breast cancer survival data set consisting of 295 tumours as collected in the National Cancer Institute in Amsterdam and previously reported in more general papers. The main aim of this paper it to show how generally accepted biostatistical procedures can be employed to analyse high-dimensional data. Copyright © 2005 John Wiley & Sons, Ltd.
Original languageUndefined/Unknown
Pages (from-to)3201-3216
Number of pages16
JournalStatistics in Medicine
Issue number18
Publication statusPublished - 2006


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