Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

Willem E.M. Noteborn, Damy N.H. Zwagerman, Victorio Saez Talens, Chandan Maity, Lars van der Mee, Jos M. Poolman, Serhii Mytnyk, Jan H. van Esch, Rienk Eelkema, More Authors

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)

Abstract

Researchers investigated the effect of various (bio)polymeric crosslinkers on the self-assembly process of this reaction-coupled hydrazide-aldehyde gelator into hydrogel materials as a model system. They selected duplex DNA, which acted as a stiff, negatively charged rigid rod below its persistence length ideal for the construction of (nano)materials,[38–40] and compared it against a soft, neutral poly(ethylene glycol) (PEG) polymer of comparable size. Aldehyde moieties were specifically incorporated at the terminal ends of the (bio)polymers to introduce them during the self-assembly of the reaction-coupled network composed another set of (bio)polymers. The researchers also examined the effect of these two crosslinkers on the gelation of the reaction-coupled monomers into hydrogels over several length scales and compared their resultant materials properties.

Original languageEnglish
Article number1603769
Number of pages7
JournalAdvanced Materials
Volume29
Issue number12
DOIs
Publication statusPublished - 2017

Keywords

  • crosslinkers
  • hydrogels
  • microstructures
  • self-assembly
  • supramolecular materials

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