Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

Willem E.M. Noteborn; Damy N.H. Zwagerman; Victorio Saez Talens; Chandan Maity; Lars van der Mee; Jos M. Poolman; Serhii Mytnyk; Jan H. van Esch; Rienk Eelkema; null More Authors

doi:10.1002/adma.201603769

Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

Willem E.M. Noteborn, Damy N.H. Zwagerman, Victorio Saez Talens, Chandan Maity, Lars van der Mee, Jos M. Poolman, Serhii Mytnyk, Jan H. van Esch, Rienk Eelkema, More Authors

Research output: Contribution to journal › Article › Scientific › peer-review

21 Citations (Scopus)

Abstract

Researchers investigated the effect of various (bio)polymeric crosslinkers on the self-assembly process of this reaction-coupled hydrazide-aldehyde gelator into hydrogel materials as a model system. They selected duplex DNA, which acted as a stiff, negatively charged rigid rod below its persistence length ideal for the construction of (nano)materials,[38–40] and compared it against a soft, neutral poly(ethylene glycol) (PEG) polymer of comparable size. Aldehyde moieties were specifically incorporated at the terminal ends of the (bio)polymers to introduce them during the self-assembly of the reaction-coupled network composed another set of (bio)polymers. The researchers also examined the effect of these two crosslinkers on the gelation of the reaction-coupled monomers into hydrogels over several length scales and compared their resultant materials properties.

Original language	English
Article number	1603769
Number of pages	7
Journal	Advanced Materials
Volume	29
Issue number	12
DOIs	https://doi.org/10.1002/adma.201603769
Publication status	Published - 2017

Keywords

crosslinkers
hydrogels
microstructures
self-assembly
supramolecular materials

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10.1002/adma.201603769

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title = "Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel",

abstract = "Researchers investigated the effect of various (bio)polymeric crosslinkers on the self-assembly process of this reaction-coupled hydrazide-aldehyde gelator into hydrogel materials as a model system. They selected duplex DNA, which acted as a stiff, negatively charged rigid rod below its persistence length ideal for the construction of (nano)materials,[38–40] and compared it against a soft, neutral poly(ethylene glycol) (PEG) polymer of comparable size. Aldehyde moieties were specifically incorporated at the terminal ends of the (bio)polymers to introduce them during the self-assembly of the reaction-coupled network composed another set of (bio)polymers. The researchers also examined the effect of these two crosslinkers on the gelation of the reaction-coupled monomers into hydrogels over several length scales and compared their resultant materials properties.",

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AU - Noteborn, Willem E.M.

AU - Zwagerman, Damy N.H.

AU - Talens, Victorio Saez

AU - Maity, Chandan

AU - van der Mee, Lars

AU - Poolman, Jos M.

AU - Mytnyk, Serhii

AU - van Esch, Jan H.

AU - Eelkema, Rienk

AU - More Authors, null

PY - 2017

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AB - Researchers investigated the effect of various (bio)polymeric crosslinkers on the self-assembly process of this reaction-coupled hydrazide-aldehyde gelator into hydrogel materials as a model system. They selected duplex DNA, which acted as a stiff, negatively charged rigid rod below its persistence length ideal for the construction of (nano)materials,[38–40] and compared it against a soft, neutral poly(ethylene glycol) (PEG) polymer of comparable size. Aldehyde moieties were specifically incorporated at the terminal ends of the (bio)polymers to introduce them during the self-assembly of the reaction-coupled network composed another set of (bio)polymers. The researchers also examined the effect of these two crosslinkers on the gelation of the reaction-coupled monomers into hydrogels over several length scales and compared their resultant materials properties.

KW - crosslinkers

KW - hydrogels

KW - microstructures

KW - self-assembly

KW - supramolecular materials

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Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel

Abstract

Keywords

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