Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System

Thomas Hollt; Nicola Pezzotti; V. van Unen; F. Koning; Elmar Eisemann; Boudewijn Lelieveldt; Anna Vilanova

doi:10.2312/egm.20191032

Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System

Thomas Hollt, Nicola Pezzotti, V. van Unen, F. Koning, Elmar Eisemann, Boudewijn Lelieveldt, Anna Vilanova

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

Abstract

Recent advances in single-cell acquisition technology have led to a shift towards single-cell analysis in many fields of biology. In immunology, detailed knowledge of the cellular composition is of interest, as it can be the cause of deregulated immune responses, which cause diseases. Similarly, vaccination is based on triggering proper immune responses; however, many vaccines are ineffective or only work properly in a subset of those who are vaccinated. Identifying differences in the cellular composition of the immune system in such cases can lead to more precise treatment. Cytosplore is an integrated, interactive visual analysis framework for the exploration of large single-cell datasets. We have developed Cytosplore in close collaboration with immunology researchers and several partners use the software in their daily workflow. Cytosplore enables efficient data analysis and has led to several discoveries alongside high-impact publications.

Original language	English
Title of host publication	Eurographics 2019
Subtitle of host publication	Dirk Bartz Prize
Editors	S. Bruckner, O.J. Steffen
Publisher	The Eurographics Association
Pages	1-4
Number of pages	4
DOIs	https://doi.org/10.2312/egm.20191032
Publication status	Published - 2019
Event	Eurographics 2019: The 40th Annual Conference of the European Association for Computer Graphics - Genova, Italy Duration: 6 May 2019 → 10 May 2019 Conference number: 40th

Conference

Conference	Eurographics 2019
Country/Territory	Italy
City	Genova
Period	6/05/19 → 10/05/19

Keywords

Human-centered computing
Information visualization;
Visualization theory
concepts and paradigms;

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2312/egm.20191032

Cytosplore
Höllt, T. (Creator), Delft University of Technology, Faculteit Elektrotechniek, Wiskunde en Informatica, 28 Jun 2017
DOI: 10.1038/s41467-017-01689-9
Dataset/Software: Software

Cite this

@inproceedings{1af22973121e496e8e5872f21d43ff9e,

title = "Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System",

abstract = "Recent advances in single-cell acquisition technology have led to a shift towards single-cell analysis in many fields of biology. In immunology, detailed knowledge of the cellular composition is of interest, as it can be the cause of deregulated immune responses, which cause diseases. Similarly, vaccination is based on triggering proper immune responses; however, many vaccines are ineffective or only work properly in a subset of those who are vaccinated. Identifying differences in the cellular composition of the immune system in such cases can lead to more precise treatment. Cytosplore is an integrated, interactive visual analysis framework for the exploration of large single-cell datasets. We have developed Cytosplore in close collaboration with immunology researchers and several partners use the software in their daily workflow. Cytosplore enables efficient data analysis and has led to several discoveries alongside high-impact publications.",

keywords = "Human-centered computing, Information visualization;, Visualization theory, concepts and paradigms;",

author = "Thomas Hollt and Nicola Pezzotti and {van Unen}, V. and F. Koning and Elmar Eisemann and Boudewijn Lelieveldt and Anna Vilanova",

year = "2019",

doi = "10.2312/egm.20191032",

language = "English",

pages = "1--4",

editor = "S. Bruckner and O.J. Steffen",

booktitle = "Eurographics 2019",

publisher = "The Eurographics Association",

note = "Eurographics 2019 : The 40th Annual Conference of the European Association for Computer Graphics ; Conference date: 06-05-2019 Through 10-05-2019",

}

Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System. / Hollt, Thomas; Pezzotti, Nicola; van Unen, V. et al.
Eurographics 2019 : Dirk Bartz Prize. ed. / S. Bruckner; O.J. Steffen. The Eurographics Association, 2019. p. 1-4.

Research output: Chapter in Book/Conference proceedings/Edited volume › Conference contribution › Scientific › peer-review

TY - GEN

T1 - Cytosplore

T2 - Eurographics 2019

AU - Hollt, Thomas

AU - Pezzotti, Nicola

AU - van Unen, V.

AU - Koning, F.

AU - Eisemann, Elmar

AU - Lelieveldt, Boudewijn

AU - Vilanova , Anna

N1 - Conference code: 40th

PY - 2019

Y1 - 2019

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AB - Recent advances in single-cell acquisition technology have led to a shift towards single-cell analysis in many fields of biology. In immunology, detailed knowledge of the cellular composition is of interest, as it can be the cause of deregulated immune responses, which cause diseases. Similarly, vaccination is based on triggering proper immune responses; however, many vaccines are ineffective or only work properly in a subset of those who are vaccinated. Identifying differences in the cellular composition of the immune system in such cases can lead to more precise treatment. Cytosplore is an integrated, interactive visual analysis framework for the exploration of large single-cell datasets. We have developed Cytosplore in close collaboration with immunology researchers and several partners use the software in their daily workflow. Cytosplore enables efficient data analysis and has led to several discoveries alongside high-impact publications.

KW - Human-centered computing

KW - Information visualization;

KW - Visualization theory

KW - concepts and paradigms;

U2 - 10.2312/egm.20191032

DO - 10.2312/egm.20191032

M3 - Conference contribution

SP - 1

EP - 4

BT - Eurographics 2019

A2 - Bruckner, S.

A2 - Steffen, O.J.

PB - The Eurographics Association

Y2 - 6 May 2019 through 10 May 2019

ER -

Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System

Abstract

Conference

Keywords

UN SDGs

Access to Document

Fingerprint

Datasets

Cytosplore

Cite this