Cytosplore: Interactive Visual Single-Cell Profiling of the Immune System

Thomas Hollt, Nicola Pezzotti, V. van Unen, F. Koning, Elmar Eisemann, Boudewijn Lelieveldt, Anna Vilanova

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review


Recent advances in single-cell acquisition technology have led to a shift towards single-cell analysis in many fields of biology. In immunology, detailed knowledge of the cellular composition is of interest, as it can be the cause of deregulated immune responses, which cause diseases. Similarly, vaccination is based on triggering proper immune responses; however, many vaccines are ineffective or only work properly in a subset of those who are vaccinated. Identifying differences in the cellular composition of the immune system in such cases can lead to more precise treatment. Cytosplore is an integrated, interactive visual analysis framework for the exploration of large single-cell datasets. We have developed Cytosplore in close collaboration with immunology researchers and several partners use the software in their daily workflow. Cytosplore enables efficient data analysis and has led to several discoveries alongside high-impact publications.
Original languageEnglish
Title of host publicationEurographics 2019
Subtitle of host publicationDirk Bartz Prize
EditorsS. Bruckner, O.J. Steffen
PublisherThe Eurographics Association
Number of pages4
Publication statusPublished - 2019
EventEurographics 2019: The 40th Annual Conference of the European Association for Computer Graphics - Genova, Italy
Duration: 6 May 201910 May 2019
Conference number: 40th


ConferenceEurographics 2019


  • Human-centered computing
  • Information visualization;
  • Visualization theory
  • concepts and paradigms;

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