Deep eutectic solvents for redox biocatalysis

Vicente Gotor-Fernández, Caroline E. Paul

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)
308 Downloads (Pure)


Deep eutectic solvents (DES) are a class of neoteric solvents used in multiple applications amongst which biocatalytic processes. Due to its simple preparation, low cost and inherent biodegradable properties, its use as a non-volatile biocompatible co-solvent with both whole cells and isolated enzymes has displayed increased enzyme activity and stability translating to higher product conversions and a surprising higher enantioselectivity in a range of biotransformations. This review lays out the latest updates on the use of DES in redox biocatalytic reactions. With that purpose, a clear division has been made to summarize the application of DES in bioreduction reactions using whole cells and purified alcohol dehydrogenases, oxidations involving alcohol dehydrogenases, heme-dependent enzymes, peroxidases, laccases and catalases, ozonolysis reactions, and finally mention the application of lipase in the mediation of chemoenzymatic epoxidation and Baeyer-Villiger reactions.

Original languageEnglish
Pages (from-to)24-35
JournalJournal of Biotechnology
Publication statusPublished - 2019


  • Deep eutectic solvents
  • Neoteric solvents
  • Non-conventional media
  • Redox biocatalysis
  • Whole cells catalysis


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