TY - JOUR
T1 - Deep eutectic solvents for redox biocatalysis
AU - Gotor-Fernández, Vicente
AU - Paul, Caroline E.
PY - 2019
Y1 - 2019
N2 - Deep eutectic solvents (DES) are a class of neoteric solvents used in multiple applications amongst which biocatalytic processes. Due to its simple preparation, low cost and inherent biodegradable properties, its use as a non-volatile biocompatible co-solvent with both whole cells and isolated enzymes has displayed increased enzyme activity and stability translating to higher product conversions and a surprising higher enantioselectivity in a range of biotransformations. This review lays out the latest updates on the use of DES in redox biocatalytic reactions. With that purpose, a clear division has been made to summarize the application of DES in bioreduction reactions using whole cells and purified alcohol dehydrogenases, oxidations involving alcohol dehydrogenases, heme-dependent enzymes, peroxidases, laccases and catalases, ozonolysis reactions, and finally mention the application of lipase in the mediation of chemoenzymatic epoxidation and Baeyer-Villiger reactions.
AB - Deep eutectic solvents (DES) are a class of neoteric solvents used in multiple applications amongst which biocatalytic processes. Due to its simple preparation, low cost and inherent biodegradable properties, its use as a non-volatile biocompatible co-solvent with both whole cells and isolated enzymes has displayed increased enzyme activity and stability translating to higher product conversions and a surprising higher enantioselectivity in a range of biotransformations. This review lays out the latest updates on the use of DES in redox biocatalytic reactions. With that purpose, a clear division has been made to summarize the application of DES in bioreduction reactions using whole cells and purified alcohol dehydrogenases, oxidations involving alcohol dehydrogenases, heme-dependent enzymes, peroxidases, laccases and catalases, ozonolysis reactions, and finally mention the application of lipase in the mediation of chemoenzymatic epoxidation and Baeyer-Villiger reactions.
KW - Deep eutectic solvents
KW - Neoteric solvents
KW - Non-conventional media
KW - Redox biocatalysis
KW - Whole cells catalysis
UR - http://www.scopus.com/inward/record.url?scp=85060890807&partnerID=8YFLogxK
U2 - 10.1016/j.jbiotec.2018.12.018
DO - 10.1016/j.jbiotec.2018.12.018
M3 - Review article
AN - SCOPUS:85060890807
SN - 0168-1656
VL - 293
SP - 24
EP - 35
JO - Journal of Biotechnology
JF - Journal of Biotechnology
ER -