TY - JOUR
T1 - Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia
AU - Ferrero, Riccardo
AU - Androulakis, Ioannis
AU - Martino, Luca
AU - Nadar, Robin
AU - van Rhoon, Gerard C.
AU - Manzin, Alessandra
PY - 2022
Y1 - 2022
N2 - The evaluation of the biological effects of therapeutic hyperthermia in oncology and the precise quantification of thermal dose, when heating is coupled with radiotherapy or chemotherapy, are active fields of research. The reliable measurement of hyperthermia effects on cells and tissues requires a strong control of the delivered power and of the induced temperature rise. To this aim, we have developed a radiofrequency (RF) electromagnetic applicator operating at 434 MHz, specifically engineered for in vitro tests on 3D cell cultures. The applicator has been designed with the aid of an extensive modelling analysis, which combines electromagnetic and thermal simulations. The heating performance of the built prototype has been validated by means of temperature measurements carried out on tissue-mimicking phantoms and aimed at monitoring both spatial and temporal temperature variations. The experimental results demonstrate the capability of the RF applicator to produce a well-focused heating, with the possibility of modulating the duration of the heating transient and controlling the temperature rise in a specific target region, by simply tuning the effectively supplied power.
AB - The evaluation of the biological effects of therapeutic hyperthermia in oncology and the precise quantification of thermal dose, when heating is coupled with radiotherapy or chemotherapy, are active fields of research. The reliable measurement of hyperthermia effects on cells and tissues requires a strong control of the delivered power and of the induced temperature rise. To this aim, we have developed a radiofrequency (RF) electromagnetic applicator operating at 434 MHz, specifically engineered for in vitro tests on 3D cell cultures. The applicator has been designed with the aid of an extensive modelling analysis, which combines electromagnetic and thermal simulations. The heating performance of the built prototype has been validated by means of temperature measurements carried out on tissue-mimicking phantoms and aimed at monitoring both spatial and temporal temperature variations. The experimental results demonstrate the capability of the RF applicator to produce a well-focused heating, with the possibility of modulating the duration of the heating transient and controlling the temperature rise in a specific target region, by simply tuning the effectively supplied power.
KW - coaxial cable
KW - electromagnetic hyperthermia
KW - electromagnetic modelling
KW - phantoms
KW - RF applicator
KW - TEM mode
KW - temperature measurements
KW - thermal modelling
KW - thermal therapies
UR - http://www.scopus.com/inward/record.url?scp=85129812785&partnerID=8YFLogxK
U2 - 10.3390/s22103610
DO - 10.3390/s22103610
M3 - Article
AN - SCOPUS:85129812785
SN - 1424-8220
VL - 22
JO - Sensors
JF - Sensors
IS - 10
M1 - 3610
ER -