Design and Custom Fabrication of a Smart Temperature Sensor for an Organ-on-a-chip Platform

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Abstract

This paper reports on the design and fabrication of a time-mode signal-processing in situ temperature sensor customized for an organ-on-a-chip (OOC) application. The circuit was fabricated using an in-house integrated circuit (IC) technology that requires only seven lithographic steps and is compatible with MEMS fabrication process. The proposed circuit is developed to provide the first out-of-incubator temperature monitoring of cell cultures on an OOC platform in a monolithic fabrication. Measurement results on wafer reveal a temperature measurement resolution of less than ±0.2 °C (3σ) and a maximum nonlinearity error of less than 0.3% across a temperature range from 25 °C to 100 °C.

Original languageEnglish
Title of host publication2018 IEEE Biomedical Circuits and Systems Conference (BioCAS)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages1-4
Number of pages4
ISBN (Electronic)978-1-5386-3603-9
ISBN (Print)978-1-5386-3604-6
DOIs
Publication statusPublished - 2018
Event2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Cleveland, United States
Duration: 17 Oct 201819 Oct 2018

Conference

Conference2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018
CountryUnited States
CityCleveland
Period17/10/1819/10/18

Keywords

  • IC MEMS co-design
  • Organ-on-a-chip
  • Smart temperature sensor
  • Time-mode signal-processing

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