Design of a molecular clock with RNA-mediated regulation

Franco Blanchini, Christian Cuba Samaniego, Elisa Franco, Giulia Giordano

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

11 Citations (Scopus)


We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.

Original languageEnglish
Title of host publicationProceedings of the IEEE Conference on Decision and Control
Number of pages6
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0743-1546


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