Design of a molecular clock with RNA-mediated regulation

Franco Blanchini, Christian Cuba Samaniego, Elisa Franco, Giulia Giordano

Research output: Chapter in Book/Conference proceedings/Edited volumeConference contributionScientificpeer-review

10 Citations (Scopus)

Abstract

We design a new negative feedback molecular oscillator and study its properties analytically and numerically. This oscillator is composed of two synthetic genes interconnected through their RNA outputs. Regulation of the genes activity is achieved by controlling the activity of the enzymes rather than the activity of the promoters. We show that a simple model of this system has the potential to oscillate for appropriate choices of the parameters. Our design can be built experimentally using RNA aptamers.

Original languageEnglish
Title of host publicationProceedings of the IEEE Conference on Decision and Control
Pages4611-4616
Number of pages6
Volume2015-February
EditionFebruary
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0743-1546

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  • Cite this

    Blanchini, F., Samaniego, C. C., Franco, E., & Giordano, G. (2014). Design of a molecular clock with RNA-mediated regulation. In Proceedings of the IEEE Conference on Decision and Control (February ed., Vol. 2015-February, pp. 4611-4616). (Proceedings of the IEEE Conference on Decision and Control). https://doi.org/10.1109/CDC.2014.7040109