Designing biocatalytic redox reactions with oxidoreductases for organic chemistry

Marine Rauch

Research output: ThesisDissertation (TU Delft)

148 Downloads (Pure)

Abstract

The focus of this thesis is to identify improvements of oxidoreductase reactions to bring them to preparative scale. Three approaches were studied: (1) photoregeneration of oxidised nicotinamide cofactors with LEDs as light source and flavins, (2) direct regeneration of Old Yellow Enzymes with light or metals, (3) heme-thiolate enzyme peroxygenases in neat substrate conditions.
Flavins are the main actors of the first two approaches. These redox cofactors have been chosen for their photocatalytic properties as a photosensitiser and as a cofactor in the so-called flavoproteins.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Delft University of Technology
Supervisors/Advisors
  • Hollmann, F., Supervisor
  • Arends, Isabel, Supervisor
  • Paul, C.E., Advisor
Award date27 Mar 2020
Print ISBNs978-94-6384-112-2
DOIs
Publication statusPublished - 7 Feb 2020

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